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Table 4 Frequency of mutations in rpoB gene codons 42, 52, 87, 92, 441, 450 and 457 in 140 RIF-resistant strains of M. tuberculosis complex

From: Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa

  rpoBgene mutation positions
  Y42 → D G52 → A H87 → G L92 → S V441 → G L450 → S L 457 → P
No. of strains (%) 30 (21.4%) 20 (14.3%) 10 (7.1%) 10 (7.1%) 10 (7.1%) 10 (7.1%) 10 (7.1%)
  1. Y = Tyrosine; D = Aspartic; G = Glycine; A = Alanine; H = Histidine; L = Leucine; S = Serine; V = Valine; P = Proline.