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Table 3 Mutations in rpoB, katG, gidB, pncA, gyrA, gyrB, rpsL, rrs, and tlyA genes associated with the formation of drug resistance and the following amino acid substitutions

From: Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia

№ rpoB katG gidB pncA gyr A gyrB rpsL rrs tlyA
6 S531L, S540R S315T E92D A-11G S95T No mutation K43R 1401 A → G L11L
9 S531L, S540R S315T E92D I5T D94A, S95T No mutation K43R 1401 A → G, DelA 1473396 L11L
15 S531L, S540R S315T L10R T-7C D94N, S95T No mutation No mutation 1401 A → G, 685 G → A L11L
17 S531L, S540R S315T E92D 48InsG D94H, S95T No mutation K43R No mutation L11L
20 L511P, D516G, S540R S315T E92D L4W S95T No mutation No mutation No mutation L11L
21 S531L, S540R S315T E92D Y99STOP A90V, S95T No mutation K43R 1401 A → G L11L
37 S531L, S540R S315T E92D T76P D94A, S95T No mutation K43R No mutation L11L
38 S531L, S540R S315T E92D L120P D94E, S95T No mutation K43R 1401 A → G L11L
48 D516V, S540R S315T L10R T76P A90V, S95T No mutation No mutation 1401 A → G N/A
78 S531L, S540R S315T E92D A28D D94G, S95T No mutation K43R No mutation N/A
87 S531L, S540R S315T E92D D12A D94G, S95T No mutation K43R No mutation N/A
94 S531L S315T E92D V139A S91P, S95T No mutation K43R 1401 A → G N/A
96 H513L S315T N/A No mutation D94N, S95T No mutation No mutation No mutation N/A
128 S531L S315T E92D Del G pos256, S179V N/A No mutation K88R 1401 A → G L11L
133* S531L S315T E92D N/A D94G, S95T No mutation K43R 1401 A → G N/A
145 L533P, S540R S315T E92D Del C pos 428 D94G, S95T No mutation K43R No mutation L11L
158 S531L S315T E92D No mutation S95T No mutation K43R 1401 A → G N/A
169 S531L, S540R S315T E92D A-11G D94Y, S95T No mutation K43R No mutation L11L
171 S531L S315T E92D No mutation S95T No mutation K43R No mutation L11L
235 S531L S315T E92D V7G A90V, S95T No mutation K43R No mutation L11L
236* S531L, S540R S315T E92D N/A D94G, S95T No mutation K43R 1401 A → G L11L
238 S531L S315T I81I, E92D V45G, I31S D94G, S95T No mutation K43R 1401 A → G L11L
275 S531L S315T E92D No mutation D94A, S95T No mutation K43R 1401 A → G L11L
276 S531L S315T N/A No mutation S95T No mutation No mutation 1401 A → G N/A
285 S531L S315T E92D L172P D94A, S95T No mutation K43R 1401 A → G L11L
287 S531L S315T N/A I31S S91P, S95T No mutation K43R 1401 A → G N/A
300 S531L, S540R S315T E92D, R102P I31S A90V, S95T No mutation K43R 1401 A → G N/A
309 S531L, S540R S315T N/A A146T A90V, S95T No mutation K43R 1401 A → G N/A
1084 S531L, S540R S315T N/A D8N D94N, S95T No mutation K43R 1401 A → G N/A
4548 S531L S315T E92D Del A pos 353 D94G, S95T No mutation K43R 1401 A → G N/A
  1. Note: *- the isolates from one patient. N/A – we could not get the sequencing.
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