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Table 5 Significant covariates within final regression models for ES and ED eligibility opportunities

From: Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections: a multi-country medical chart review in Europe

Level ES eligibility (n = 1542) ED eligibility (n = 1542)
  OR (95% CI) OR (95% CI)
Intercept   
Patient baseline characteristics  
Country (vs Ireland/United Kingdom)   
  Czech Republic 0.91 (0.38–2.17) 2.18 (1.01–4.67)*
  Germany 2.47 (1.55–3.92)*** 2.05 (1.30–3.24)**
  Greece 3.30 (1.99–5.48)*** 1.39 (0.84–2.30)
  Portugal 1.75 (1.04–2.95)* 1.67 (0.99–2.83)
  Slovakia 0.55 (0.20–1.46) 0.29 (0.10–0.82)*
Patient living arrangements (vs at home with caregiver)   
  Alone without caregiver   1.33 (1.03–1.72)*
Dementia 0.46 (0.28–0.76)** 0.50 (0.30–0.83)**
Infection/ treatment characteristics  
Hospital-acquired or healthcare-associated infection 1.75 (1.30–2.37)*** 1.69 (1.25–2.27)***
Days to first MRSA culture (vs on or before cSSTI index date)   
  No MRSA culture documented 0.46 (0.30–0.69)*** 0.58 (0.40–0.85)**
Days from admission to cSSTI index date (vs cSSTI at admission)   
  ≥4 days after admission 0.47 (0.32–0.70)* 0.55 (0.38–0.79)
MRSA-targeted therapy patterns (vs IV-only)   
  IV-to-oral antibiotic switch 0.49 (0.33–0.72)*** 1.40 (1.00–1.96)
Time to initiating MRSA-active therapy (vs on or before cSSTI index date)   
  1–2 days post cSSTI index date   1.20 (0.92–1.56)**
  ≥3 days post cSSTI index date   0.71 (0.51–0.99)**
Any surgical procedures for cSSTI 1.13 (0.87–1.45) 1.04 (0.82–1.32)
Complications  
Developed IV line infection 0.19 (0.06–0.56)**  
Hospital characteristics  
Hospital had an IV-to-oral antibiotic switch protocol   0.58 (0.43–0.80)***
Hospital had an ED protocol (IV-to-oral antibiotic switch or OPAT)   1.86 (1.31–2.64)***
  1. *p < 0.05; **p < 0.01; ***p < 0.001.
  2. Full versions of the final models, including covariates that were statistically non-significant, are in Appendix Table 1.
  3. Abbreviations: CCI, Charlson comorbidity index; CI, confidence interval; cSSTI, complicated skin and soft tissue infection; IV, intravenous; ED, early discharge; ES, early switch; GP, general practitioner; IM, internal medicine specialist; LOS, length of hospital stay; MRSA, methicillin-resistant Staphylococcus aureus; OPAT, outpatient parenteral antibiotic therapy; SAE, serious adverse event; SE, standard error.