Table 4 Significant covariates within final regression models for actual treatment patterns

Intercept

–

5.98 (1.71)***

24.72 (2.47)***

Patient baseline characteristics

Country (vs Ireland/United Kingdom)

  Austria

0.17 (0.04–0.76)*

2.74 (1.49)

2.48 (2.64)

  France

1.44 (0.81–2.57)

4.24 (0.93)***

6.23 (1.66)***

  Germany

0.40 (0.21–0.78)**

4.16 (0.97)***

4.28 (1.74)*

  Greece

0.05 (0.01–0.18)***

2.53 (1.14)*

1.25 (2.03)

  Italy

0.23 (0.10–0.55)***

2.91 (1.04)**

4.69 (1.87)*

  Poland

0.19 (0.04–0.90)*

7.65 (1.69)***

5.97 (2.93)*

  Portugal

0.16 (0.06–0.40)***

4.41 (1.18)***

4.46 (2.12)*

  Slovakia

0.67 (0.23–1.93)

5.29 (1.83)**

3.32 (3.14)

  Spain

0.90 (0.49–1.65)

3.10 (1.01)**

5.26 (1.81)**

IV drug abuse

0.72 (0.38–1.34)

2.78 (0.88)**

4.95 (1.72)**

CCI (continuous)

0.96 (0.89–1.04)

0.27 (0.12)*

0.44 (0.21)*

Any MRSA colonization before admission

1.77 (1.13–2.77)*

  Not reported/unknown

1.78 (1.19–2.67)**

Infection/treatment characteristics

cSSTI type (vs deep/extensive cellulitis)

  Surgical site infection or posttraumatic wound

1.26 (0.77–2.07)

−1.39 (0.70)*

−2.07 (1.24)

cSSTI location (vs torso/abdomen)

  Upper extremity

1.90 (1.09–3.33)*

−1.62 (0.80)*

−4.97 (1.43)***

Hospital-acquired or healthcare-associated infection unknown/undocumented

0.98 (0.60–1.59)

−2.40 (0.68)***

−2.21 (1.20)

Days from admission to cSSTI index date (vs cSSTI at admission)

  ≥4 days after admission

1.13 (0.64)

5.57 (1.13)***

MRSA-targeted therapy patterns (vs IV-only)

  IV-to-oral antibiotic switch

–

−5.19 (0.74)***

−1.86 (1.32)

  Discharged on OPAT

–

−2.64 (1.59)

−6.92 (2.85)*

  No MRSA-active antibiotic

–

–

−7.52 (2.98)*

Initial antibiotic therapy was MRSA active (vs was not MRSA active)

0.41 (0.24 - 0.70)**

5.84 (1.01)***

Time to initiating MRSA-active therapy (vs on or before cSSTI index date)

  1–2 days post cSSTI index date

−1.34 (0.39)***

−2.03 (0.66)**

   ≥3 days post cSSTI index date

2.20 (0.53)***

4.18 (0.80)***

Physician specialty (vs GP)^a

  IM

2.26 (1.43–3.56)***

1.18 (0.64)

2.86 (1.13)*

  Infectious disease

3.01 (1.88–4.82)***

2.39 (0.73)**

1.28 (1.30)

  Surgeon

1.31 (0.70–2.45)

2.73 (0.87)**

5.78 (1.55)***

Any surgical procedures for cSSTI

1.46 (1.00–2.12)*

0.81 (0.54)

1.80 (0.96)

Complications

Severe sepsis

1.93 (0.32)***

2.32 (0.59)***

Superinfection

3.32 (0.95)***

Developed IV line infection

Hospital characteristics

Overall hospital beds (vs ≥1000)

  10–249

2.37 (1.45–3.88)***

−2.17 (0.77)**

−2.17 (1.37)

Hospital had an IV-to-oral antibiotic switch protocol

0.88 (0.61)

−2.13 (1.08)*