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Table 4 Immunological responses* among HIV-2 –infected patients in 17 studies

From: Antiretroviral therapy response among HIV-2 infected patients: a systematic review

Study (Author, year) CD4 count Baseline Median [IQR] CD4 count Month-6 Median [IQR] CD4 count Month-12 Median [IQR] CD4 count Month -24 Median [IQR] Delta of CD4 count cells/mm3 Slope of CD4 count (first period) Slope of CD4 count (second period) Comments
Adje-Touré, 2003 [34] 82 [52–188] 154 [68–275] 163 [132–244] NR NR NR NR NR
Van Der Ende, 2003 [29] 90 [10–360] 230 [40–380] 270 [60–410] NR NR NR NR 13 patients (Group II)
Mullins 2004 [39] 134[93–205] NR NR NR NR NR NR Median of CD4 count at the last visit
327 [202–408]
Matheron, 2006 [40] 136 [57–244] 177 181 221 M6: +53 (+10; +86) NR NR At 12 months
[98–328] [123–290] [133–374]     No PI: +40 (+18; +97)
    M12: +41 (+9; +92)    
    M24: +62 (9; 120)    PI: (+41 (+8, +86)
       P (0.67)
Ndour, 2006 [41] 204 [12–1029] NR NR NR Month-12 NR NR NR
    +200 cells/mm3    
Drylewicz, 2008 [12] 267 [163–381] NR NR NR NR <2 months 25 (7; 42) cells/μl/months >2 months-3 (-38; +32) cells/μl/year Slope of % of CD4 count was reported
Ruelle 2008 [42] 226 [124–359] NR NR NR PI containing regimens: +89 cells/mm3 [-31; 323]   PI group 106 cells/μl/year  
PI sparing regimens-53 cells/mm3 [-62; 57] Without PI-25 cells/μl/year
Benard A, 2009 [28] 142 [59–259]     M6: +71 [11–116] M12: +122 [61–159] M24 + 132 [110–275] <3 months 24.3 (7.1; 41.4) cells/μl/months >3 months +8.50 (+5.3; +11.7) cells/μl/year  
Jallow, 2009 [31] 145 [65–210] NR NR NR NR NR NR NR
Gottlieb, 2009 [23] 200 [12–562] NR NR NR NR NR NR NR
Harries, 2010 [17] 111 [31–171] NR NR NR NR NR NR Means CD4 count M6 = 255, M12 = 270
Drylewicz 2010 [30] 178 [77–232] NR PI 278 [248–307] NNRTIs 268 [175–293] NR NR <3 months NNRTIs: -41 (-123; 40) cells/μl/year >3 months +8.50 (+5.3; +11.7) cells/μl/year  
Smith 2010 [43] 202 [2–1124] NR NR NR    +8 [-100; +181] cells/mm3/year 64% CD4 increase and 37% cd4 decline in follow-up
Chiara, 2010 [44] 96 [73–111] (3NRTIs)/PI (114)/78 3NRTIs/PI (102)/171 3NRTIs/PI (91)/254 NR NR NR NR NR
Peterson 2011 [18] 140 [50–310] NR NR NR M6: +120 cells M12: +115 cells M24: +285 cells M36: +280 NR NR NR
Benard, 2011 [15] 216 [150–287] PI: 191 [90–275] 3NRTI: 170 [72–275] NR PI (327) 3NRTI (191) NR NR <3 months PI: +12 cells/μl/months 3NRTI: +6 cells/μl/months 3-12 months PI: +76 cells/μl/y 3NRTI: -60 cells/μl/y > = 200 cells/mm3 PI: +52 cells/μl/y 3NRTI: -99 cells/μl/y
Peterson K, 2012 [45] 181 [96–200] NR NR NR NR NR NR NR
  1. *Included only the study who reported immunological responses.
  2. NR: Not Reported.