Figure 4

Sequence analysis of CKR-L3- and CCR6-variant of HIV-2MIR and SIVsmE660 isolates. The alignment of the C2-V3 amino acid sequences of the HIV-2MIR for CKR-L3- and CCR6-variant has been made with the parental CCR5-variant. Similarly, alignment was made of the V1-V3 amino acid sequences of the SIVsmE660 for the three variants. a) Each clone of CCR5-, CKR-L3- and CCR6-variant of HIV-2MIR has been aligned. Dots indicate identity and letters represent substitutions in the adapted variants relative to the parental isolate. The positions of the common amino acid changes are marked by ♦. The V3 domain is marked by dashes. b) Amino acid sequences of the three clones each from CCR5-, CKR-L3- and CCR6-variant of SIVsmE660 covering the V1-V3 domains were aligned. The regions equivalent to V1, V2 and V3 are indicated by dashes. Dots indicate the identity with the parental isolate; letters represent differences in the adapted variants. The positions of common amino acid changes are marked by ▲.