Table 4 Performance characteristics of biomarkers significantly different in dengue fever following adjustment for multiple comparisons
From: Host biomarkers distinguish dengue from leptospirosis in Colombia: a case–control study
AUC (95% CI) | Cut-off* | Sensitivity (95% CI) | Specificity (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) | |
|---|---|---|---|---|---|---|
Angiopoietin-like 3 | 0.81 (0.74–0.87) | >135.75 | 84.1 (76.0–90.3) | 63.8 (48.5–77.3) | 2.3 (1.8–2.9) | 0.3 (0.1–0.5) |
IL-18BP | 0.92 (0.87–0.96) | >24.52 | 94.7 (88.8–98.0) | 83.0 (69.2–92.4) | 5.6 (4.9–6.4) | 0.06 (0.02–0.2) |
CXCL10 | 0.84 (0.77–0.89) | >0.96 | 82.3 (74.0–88.8) | 72.3 (57.4–84.4) | 2.9 (2.4–3.6) | 0.2 (0.1–0.5) |
Platelet Factor 4 a | 0.69 (0.61–0.76) | >29.98 a | 39.8 (30.7–49.5) | 97.9 (88.7–99.9) | 18.7 (14.9–23.6) | 0.6 (0.1–4.3) |
sICAM-1 | 0.84 (0.77–0.89) | >285.9 | 83.2 (75.0–89.6) | 78.7 (64.3–89.3) | 3.9 (3.3–4.6) | 0.2 (0.1–0.4) |
Factor D | 0.85 (0.79–0.90) | >1248.1 | 69.0 (59.6–77.4) | 93.6 (82.5–98.7) | 10.8 (9.4–12.5) | 0.3 (0.1–1.1) |
sEng | 0.92 (0.86–0.96) | >9.12 | 79.7 (71.0–86.6) | 93.6 (82.5–98.7) | 12.5 (11.1–14.1) | 0.2 (0.07–0.7) |
sKDR | 0.71 (0.64–0.78) | >5.18 | 84.1 (76.0–90.3) | 51.1 (36.1–65.9) | 1.7 (1.3–2.3) | 0.3 (0.2–0.5) |
sTie-2 | 0.73 (0.65–0.80) | ≤ 9.18 | 72.6 (63.4–80.5) | 68.1 (52.9–80.9) | 2.3 (1.8–2.9) | 0.4 (0.2–0.7) |