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Table 4 Performance characteristics of biomarkers significantly different in dengue fever following adjustment for multiple comparisons

From: Host biomarkers distinguish dengue from leptospirosis in Colombia: a case–control study

  AUC (95% CI) Cut-off* Sensitivity (95% CI) Specificity (95% CI) Positive LR (95% CI) Negative LR (95% CI)
Angiopoietin-like 3 0.81 (0.74–0.87) >135.75 84.1 (76.0–90.3) 63.8 (48.5–77.3) 2.3 (1.8–2.9) 0.3 (0.1–0.5)
IL-18BP 0.92 (0.87–0.96) >24.52 94.7 (88.8–98.0) 83.0 (69.2–92.4) 5.6 (4.9–6.4) 0.06 (0.02–0.2)
CXCL10 0.84 (0.77–0.89) >0.96 82.3 (74.0–88.8) 72.3 (57.4–84.4) 2.9 (2.4–3.6) 0.2 (0.1–0.5)
Platelet Factor 4 a 0.69 (0.61–0.76) >29.98 a 39.8 (30.7–49.5) 97.9 (88.7–99.9) 18.7 (14.9–23.6) 0.6 (0.1–4.3)
sICAM-1 0.84 (0.77–0.89) >285.9 83.2 (75.0–89.6) 78.7 (64.3–89.3) 3.9 (3.3–4.6) 0.2 (0.1–0.4)
Factor D 0.85 (0.79–0.90) >1248.1 69.0 (59.6–77.4) 93.6 (82.5–98.7) 10.8 (9.4–12.5) 0.3 (0.1–1.1)
sEng 0.92 (0.86–0.96) >9.12 79.7 (71.0–86.6) 93.6 (82.5–98.7) 12.5 (11.1–14.1) 0.2 (0.07–0.7)
sKDR 0.71 (0.64–0.78) >5.18 84.1 (76.0–90.3) 51.1 (36.1–65.9) 1.7 (1.3–2.3) 0.3 (0.2–0.5)
sTie-2 0.73 (0.65–0.80) ≤ 9.18 72.6 (63.4–80.5) 68.1 (52.9–80.9) 2.3 (1.8–2.9) 0.4 (0.2–0.7)
  1. *Concentration in ng/mL unless otherwise indicated, aμg/mL.
  2. ROC curve analysis- non-parametric analysis by method of Delong et al. with the confidence interval estimated using binomial.