Table 3 Adipokines and hormones related to body composition according to four categories of body composition
|  | No lipodystrophy N = 23 | Isolated central fat accumulation N = 56 | Isolated lipoatrophy N = 78 | Mixed forms of lipodystrophy N = 60 | P |
|---|---|---|---|---|---|
Age [years, mean (SD)] | 39.9 (11.3) | 46.5 (12.6) | 44.1 (9.7) | 52.6 (10.8) | <0.001 |
BMI [kg/m2, mean (SD)] | 23.0 (2.4) | 29.1 (4.4) | 21.9 (2.8) | 26.5 (3.2) | <0.001 |
Adiponectin [μg/mL, median (25th and 75th percentile)] | 4.40 (2.43-8.75) | 1.90 (0.89-3.48) | 2.64 (1.20-6.53) | 2.81 (1.04-5.22) | 0.02 |
Leptin [ng/mL, median (25th and 75th percentile)] | 3.0 (2.0-5.7) | 10.3 (5.3-15.1) | 2.1 (1.4-3.3) | 4.3 (2.4-7.0) | <0.001 |
Resistin [ng/mL, median (25th and 75th percentile)] | 9.1 (7.9-12.6) | 10.3 (7.2-12.0) | 9.5 (8.1-15.3) | 11.2 (8.1-16.4) | 0.36 |
Ghrelin [pg/mL, median (25th and 75th percentile)] | 72.0 (52.4-110.3) | 71.0 (41.3-110.8) | 81.9 (46.2-194.3) | 79.7 (52.4-122.4) | 0.42 |
PAI-1 [pg/mL, median (25th and 75th percentile)] | 111.9 (64.8-162.8) | 40.4 (30.6-45.8) | 61.3 (28.3-96.4) | 68.7 (34.6-109.6) | 0.047 |
TNF-α [pg/mL, median (25th and 75th percentile)] | 42.8 (33.1-60.5) | 41.6 (27.7-83.4) | 49.8 (30.7-72.6) | 43.7 (29.6-79.8) | 0.91 |
Adiponectin/leptin ratio median (25th and 75th percentile) | 1.30 (0.97-2.50) | 0.19 (0.06-0.38) | 1.17 (0.43-4.60) | 0.73 (0.20-1.43) | <0.001 |