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Table 4 Univariate and multivariable matched analysis of potential risk factors preceding enrolment in infants with non-congenital invasive candidiasis

From: Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Factors frequency (%) or median (range) unless otherwise stated

Cases

Controls

Univariate odds ratio

Multivariable odds ratio

N = 34

N = 62

(95% CI) [p value]

(95% CI) [p value]a

Central line present

32 (97)

60 (94)

1.41 (0.19- 10.0)

-

[0.73]

Central line duration (days)

15.5 (2–37)

14 (2–56)

[0.46]

-

Not on enteral feeds

8 (24%)

4 (6%)

4.28 (1.08-16.54)

-

[0.04]

Duration intravenous lipid (days)

16 (7–69)

15 (1–35)

[0.09]

1.25 (1.01-1.56)

[0.0.049]

Duration intravenous amino acid (days)

16 (3–70)

16 (6–38)

0.12

-

NEC preceding IC b

12 (35)

6 (10)

7.04 (1.50-33.30)

4.81 (1.14-20.41)

[0.01]

[0.03]

Bacterial infection including UTI

17 (50)

19 (31)

2.26 (0.96-5.36)

2.79 (0.57-13.68)

[0.10]

[0.21]

Any antifungal therapy prior to IC onset

13 (35)

10 (17)

2.21 (0.71-6.85)

-

[0.17]

Prior GI surgery

2 (6)

2 (3)

2.59 (0.03-33.00)

-

[0.43]

H 2 blocker

9 (27)

7 (11)

2.94 (0.96-9.09)

0.67 (0.13-3.46)

[0.06]

[0.63]

Steroids

10 (29)

13 (21)

1.25 (0.34-4.57)

-

[0.74]

Theophylline

3 (9)

3 (5)

1.56 (0.24-10.56)

 

[0.64]

Intubation (median days)

10 (1–71)

9.5 (1–31)

0.67

-

Broad spectrum antibiotics

26 (76)

37 (60)

1.06 (0.97-1.15)

 
   

0.20

 
  1. TPN, total parenteral nutrition.
  2. aOnly available for factors included in final model; the variable ‘not on enteral feeds’ was not included in the model because this variable overlapped considerably with the variable NEC.
  3. bNEC severity was at least stage 2 in 87% of affected cases and 100% of affected controls.
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BMC Infectious Diseases

ISSN: 1471-2334

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