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Table 4 Univariate and multivariable matched analysis of potential risk factors preceding enrolment in infants with non-congenital invasive candidiasis

From: Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls

Factors frequency (%) or median (range) unless otherwise stated Cases Controls Univariate odds ratio Multivariable odds ratio
N = 34 N = 62 (95% CI) [p value] (95% CI) [p value]a
Central line present 32 (97) 60 (94) 1.41 (0.19- 10.0) -
[0.73]
Central line duration (days) 15.5 (2–37) 14 (2–56) [0.46] -
Not on enteral feeds 8 (24%) 4 (6%) 4.28 (1.08-16.54) -
[0.04]
Duration intravenous lipid (days) 16 (7–69) 15 (1–35) [0.09] 1.25 (1.01-1.56)
[0.0.049]
Duration intravenous amino acid (days) 16 (3–70) 16 (6–38) 0.12 -
NEC preceding IC b 12 (35) 6 (10) 7.04 (1.50-33.30) 4.81 (1.14-20.41)
[0.01] [0.03]
Bacterial infection including UTI 17 (50) 19 (31) 2.26 (0.96-5.36) 2.79 (0.57-13.68)
[0.10] [0.21]
Any antifungal therapy prior to IC onset 13 (35) 10 (17) 2.21 (0.71-6.85) -
[0.17]
Prior GI surgery 2 (6) 2 (3) 2.59 (0.03-33.00) -
[0.43]
H 2 blocker 9 (27) 7 (11) 2.94 (0.96-9.09) 0.67 (0.13-3.46)
[0.06] [0.63]
Steroids 10 (29) 13 (21) 1.25 (0.34-4.57) -
[0.74]
Theophylline 3 (9) 3 (5) 1.56 (0.24-10.56)  
[0.64]
Intubation (median days) 10 (1–71) 9.5 (1–31) 0.67 -
Broad spectrum antibiotics 26 (76) 37 (60) 1.06 (0.97-1.15)  
    0.20  
  1. TPN, total parenteral nutrition.
  2. aOnly available for factors included in final model; the variable ‘not on enteral feeds’ was not included in the model because this variable overlapped considerably with the variable NEC.
  3. bNEC severity was at least stage 2 in 87% of affected cases and 100% of affected controls.