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Table 2 Factors associated with undetectable HIV-RNA level (≤400 copies/mL), Rio de Janeiro, Brazil, 1997-2011

From: Improved virologic outcomes over time for HIV-infected patients on antiretroviral therapy in a cohort from Rio de Janeiro, 1997–2011

 

Unadjusted OR (95% CI)

P-value

Adjusted OR (95% CI)

P-value

Year

1.2 (1.17 - 1.22)

<0.001

1.18 (1.16 - 1.21)

<0.001

Ethnicity

    

White

1.00 (reference)

 

1.00 (reference)

 

Non-white

0.98 (0.86 - 1.1)

0.70

0.97 (0.84 - 1.11)

0.62

Risk group

    

Heterosexual man

1.00 (reference)

 

1.00 (reference)

 

Heterosexual woman

0.83 (0.7 - 0.98)

0.03

0.93 (0.78 - 1.12)

0.46

MSM

1.02 (0.86 - 1.2)

0.85

1.05 (0.87 - 1.27)

0.61

IDU

0.48 (0.31 - 0.75)

<0.01

0.88 (0.5 - 1.56)

0.66

Unknown

0.99 (0.8 - 1.27)

0.91

1.08 (0.86 - 1.37)

0.50

Other

0.46 (0.28 - 0.75)

<0.001

0.78 (0.46 - 1.3)

0.34

Education (years)

    

≤8

1.00 (reference)

 

1.00 (reference)

 

>8

1.66 (1.46 - 1.88)

<0.001

1.69 (1.47 - 1.95)

<0.001

Age* (years)

    

<30

1,00 (reference)

 

1.00 (reference)

 

30-39

1.14 (0.94 - 1.37)

0.19

1.22 (0.98 - 1.5)

0.07

40-49

1.55 (1.27 - 1.88)

<0.001

1.68 (1.34 - 2.11)

<0.001

≥50

1.98 (1.57 - 2.49)

<0.001

2.11 (1.61 - 2.77)

<0.001

Years since HIV diagnosis*

0.98 (0.97 - 1)

0.01

0.92 (0.91 - 0.94)

<0.001

Pre-treatment CD4+

    

≤200

1.00 (reference)

 

1.00 (reference)

 

201-350

1.01 (0.87 - 1.18)

0.87

0.97 (0.82 - 1.14)

0.73

351-500

1.19 (0.95 - 1.5)

0.12

1.3 (1.02 - 1.64)

0.03

>500

0.64 (0.49 - 0.83)

<0.001

0.93 (0.7 - 1.24)

0.62

Missing

0.75 (0.62 - 0.89)

<0.001

0.84 (0.69 - 1.02)

0.08

Initial regimen

    

NRTI + NNRTI

1.00 (reference)

 

1.00 (reference)

 

NRTI + PI

0.56 (0.5 - 0.64)

<0.001

0.72 (0.63 - 0.83)

<0.001

ART interruption*

    

≤1 month

1.00 (reference)

 

1.00 (reference)

 

>1 month

0.29 (0.25 - 0.37)

<0.001

0.32 (0.27 - 0.38)

<0.001

Hep C coinfection*

1.01 (0.8 - 1.27)

0.95

1.09 (0.84 - 1.42)

0.50

  1. Results from unadjusted and adjusted logistic regression generalized estimating equations models. A total of 1,492 missing midyear viral load outcomes were excluded from the analysis. OR, odds ratio; CI, confidence interval; MSM, men who have sex with men; IDU, injecting drug user; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; Hep, Hepatitis. *Time-updated variables. Bold text indicates p-value < 0.05.