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Table 5 Mean values of A/H1N1/California/7/2009-specific Abs and IFN-γ production in study participants with or without pdmH1N1 vaccination who reported symptoms of ILI during the 2009–2010 flu season

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

  Not vaccinated Vaccinated Difference
  A C C-A A C C-A C-A V-N1 P-value
  SRH (mm 2 ), geometric mean   
A/H1N1/California 15.3 19.5 4.2 18.8 28.0 9.2 5.0 0.1
  IFN-γ (pg/mL)   
A/H1N1/Brisbane 169 166 −2 113 296 183 185 <0.001
A/H1N1/Solomon 130 180 50 80 262 182 132 <0.01
A/H3N2/Uruguay 197 250 53 177 336 159 106 0.01
A/H3N2/Wisconsin 217 248 32 185 343 157 125 0.02
A/H5N1/Vietnam 330 374 44 310 403 93 49 0.3
B/Florida 254 276 22 177 263 85 63 0.4
B/Malaysia 173 203 30 108 208 101 71 0.08
M1 43 34 −10 31 62 31 41 0.09
M2 18 18 0 18 18 0 0 0.3
CFP-10 18 20 2 22 19 −3 −5 0.7
PHA 505 557 53 498 536 39 −14 0.9
Mean IFN-γ diff. 168 200 33 146 230 84 51  
N 49 49   47 47    
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate the p-values (comparison of C-A between vaccinated and unvaccinated). 1V-N is vaccinated minus unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
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