|
Time point
|
A
|
C
|
A
|
C
|
|---|
| |
2006-2009 seasonal flu vacc.
| |
|---|
| |
Vacc.
|
Not vacc.
|
Vacc.
|
Not vacc.
|
V/NV1x-diff.
|
|---|
| |
SRH (mm2), geometric mean (C.I.)
|
p-value
|
|---|
|
A/H1N1/California
|
18.3 (14.2–23.7)
|
19.6 (17.5–22.0)
|
19.1 (15.5–23.6)
|
21.2 (19.2–23.4)
|
0.5
|
0.5
|
| |
IFN-γ (pg/mL), mean
| |
|
A/H1N1/Brisbane
|
99
|
144
|
168
|
172
|
0.04
|
0.6
|
|
A/H1N1/Solomon
|
85
|
122
|
152
|
153
|
0.03
|
0.3
|
|
A/H3N2/Uruguay
|
137
|
190
|
221
|
245
|
0.12
|
0.3
|
|
A/H3N2/Wisconsin
|
162
|
206
|
226
|
261
|
0.3
|
0.2
|
|
A/H5N1/Vietnam
|
325
|
361
|
377
|
373
|
0.4
|
0.9
|
|
B/Florida
|
204
|
265
|
260
|
289
|
0.04
|
0.4
|
|
B/Malaysia
|
154
|
173
|
164
|
212
|
0.14
|
0.2
|
|
M1
|
24
|
37
|
35
|
33
|
0.14
|
0.14
|
|
M2
|
18
|
18
|
19
|
21
|
0.7
|
0.7
|
|
CFP-10
|
20
|
22
|
18
|
23
|
0.4
|
0.3
|
|
PHA
|
518
|
512
|
545
|
544
|
0.6
|
0.5
|
|
N
|
57
|
175
|
57
|
175
| | |
|
Mean age, years
|
50
|
38
|
50
|
38
|
<0.001
|
<0.001
|
- The Wilcoxon-Mann–Whitney rank-sum test was used to calculate p-values. 1V/NV: vaccinated vs. unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as a control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
