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Table 1 Mean values of A/H1N1/California/7/2009-specific Abs (measured by SRH) and IFN-γ production (in whole-blood assay) before (A) and after (C) the 2009–2010 flu season, in blood from study participants with our without seasonal flu vaccination (2006–2009)

From: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

Time point A C A C
  2006-2009 seasonal flu vacc.  
  Vacc. Not vacc. Vacc. Not vacc. V/NV1x-diff.
  SRH (mm2), geometric mean (C.I.) p-value
A/H1N1/California 18.3 (14.2–23.7) 19.6 (17.5–22.0) 19.1 (15.5–23.6) 21.2 (19.2–23.4) 0.5 0.5
  IFN-γ (pg/mL), mean  
A/H1N1/Brisbane 99 144 168 172 0.04 0.6
A/H1N1/Solomon 85 122 152 153 0.03 0.3
A/H3N2/Uruguay 137 190 221 245 0.12 0.3
A/H3N2/Wisconsin 162 206 226 261 0.3 0.2
A/H5N1/Vietnam 325 361 377 373 0.4 0.9
B/Florida 204 265 260 289 0.04 0.4
B/Malaysia 154 173 164 212 0.14 0.2
M1 24 37 35 33 0.14 0.14
M2 18 18 19 21 0.7 0.7
CFP-10 20 22 18 23 0.4 0.3
PHA 518 512 545 544 0.6 0.5
N 57 175 57 175   
Mean age, years 50 38 50 38 <0.001 <0.001
  1. The Wilcoxon-Mann–Whitney rank-sum test was used to calculate p-values. 1V/NV: vaccinated vs. unvaccinated. Listed are Ab responses (top panel, directed against A/H1N1 California, mean and confidence interval) and IFN-γ responses directed against a broad panel of flu targets (designated the flu A or flu B strains), and against matrix proteins M1 and M2. CFP10 served as a control. PHA was the positive control stimulus. P values below 0.05 are indicated in bold.
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