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Table 3 Demographic and clinical characteristics of patients with K. pneumoniae blood stream infections stratified by survivors versus non-survivors

From: Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonellamodel and a pilot study to translate to patient outcomes

Variable Survived (n = 63) Died (n = 12) p-value
Age (mean, SD) 58.8 (16.6) 64 (11.7) 0.30
Gender, female 32 (50.8) 8 (66.7) 0.36
Modified APACHE II score (mean, SD) 10.6 (4.3) 13.2 (4.9) 0.07
Prior hospitalization 29 (46) 11 (91.7) <0.01
Neutropenic 2 (3.2) 0 (0) 0.99
Renal dysfunction 7 (11.1) 6 (50) <0.01
Liver dysfunction 6 (9.5) 1 (8.3) 0.99
Diabetes 7 (11.1) 4 (33.3) 0.07
Current immunosuppressive therapy 10 (15.9) 2 (16.7) 0.99
LOS prior to positive culture (median, IQR) 1 (1–1) 10.5 (2.5-23) <0.01
Time to directed therapy (hrs) (median, IQR) 6 (3–15.5) 0 (0–5.25) <0.01
K. pneumoniae cultured from >1 site 24 (38.1) 6 (50) 0.44
Total days of antibiotics post infection (median, IQR) 7 (4–14) 9 (5–15.5) 0.56
KPC(+) status 10 (15.9) 5 (41.7) 0.055
  1. Note: Data are no. (%) of patients unless otherwise indicated.
  2. KPC = Klebsiella pneumoniae producing carbapenemase, APACHE = Acute Physiology and Chronic Health Evaluation, LOS = length of stay, SD = standard deviation, IQR = interquartile range.