Table 5 Associations between infection by ‘ancient’ and ‘modern’ M. tuberculosis sublineages (according to Gagneux et al.[22]) and clinical manifestations

Age (years)¹

-0.6

[-4.80 – 3.68]

0.80

1.0

[-3.89 – 5.93]

0.68

-1.4

[-5.84 – 3.11]

0.55

Weight (kg/m²)²

-2.0

[-1.63 – 0.16]

0.11

-1.7

[-4.82 – 1.42]

0.29

-2.4

[-5.25 – 0.44]

0.1

BMI (kg/m²)²

-0.7

[-1.63 – 0.16]

0.11

-0.5

[-1.52 – 0.52]

0.33

-1.0

[-1.89 - -0.03]

0.05

CRP (mg/L)²

14.2

[-4.20 – 32.52]

0.13

8.0

[-13.18 – 29.21]

0.46

18.5

[-0.85 – 37.76]

0.06

AGP (g/L)^1*

0.3

[0.005 – 0.59]

0.05 ³

0.2

[-0.11 – 0.55]

0.19

0.4

[0.06 – 0.66]

0.02

Neutrophil count (x 10⁹ cells/L)²

0.6

[-0.13 – 1.32]

0.11

0.1

[-0.71 – 0.96]

0.77

0.9

[0.12 – 1.64]

0.02

Lymphocyte count (x 10⁹ cells/L)²

0.2

[-0.16 – 0.49]

0.32

0.3

[-0.08 – 0.67]

0.12

0.1

[-0.26 – 0.42]

0.65

CD4 count (cells/ul)²

-21.2

[-122.66 – 80.36]

0.68

21.9

[-95.47 – 139.35]

0.71

-45.9

[-152.95 – 61.19]

0.40

Hemoglobin (g/dl)²

0.03

[-0.68 – 0.75]

0.93

0.3

[-0.50 – 1.15]

0.44

-0.2

-0.91 – 0.59

0.67

Fasting blood glucose (mmol/L)²

0.1

[-0.32 – 0.51]

0.65

-0.02

[-0.48 – 0.45]

0.95

0.1

[1.71 – 5.08]

0.59

Diabetes (Yes)²

1.5

[0.55 – 4.24]

0.42

1.2^¶

[0.35 – 3.75]

0.81

1.7^¶

[0.60 – 4.97]

0.27

Smoking (Yes)²

2.6

[0.32 – 20.81]

0.38

1.5^¶

[0.54 – 3.97]

0.46

0.9^¶

[0.32 – 2.23]

0.74

TB contact (Yes)²

1.3

0.59 – 2.70

0.55

0.2^¶

[0.50 – 2.90]

0.67

1.2^¶

[0.56 – 2.76]

0.59

BCG scar²

1.5

[0.63 – 3.32]

0.39

1.1^¶

[0.43 – 2.83]

0.83

1.7^¶

[0.69 – 4.13]

0.25