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Table 5 Associations between infection by ‘ancient’ and ‘modern’ M. tuberculosis sublineages (according to Gagneux et al.[22]) and clinical manifestations

From: Increased level of acute phase reactants in patients infected with modern Mycobacterium tuberculosis genotypes in Mwanza, Tanzania

Groups Reference group: ‘Ancient’ (n = 42) Reference group: Indo-Oceanic (n = 42)
‘Modern’ (n = 183) EAI (n = 64) Euro-American (116)
Variables Regression coefficient 95% CI P-value Regression coefficient 95% CI P-value Regression coefficient 95% CI P-value
Age (years)1 -0.6 [-4.80 – 3.68] 0.80 1.0 [-3.89 – 5.93] 0.68 -1.4 [-5.84 – 3.11] 0.55
Weight (kg/m2)2 -2.0 [-1.63 – 0.16] 0.11 -1.7 [-4.82 – 1.42] 0.29 -2.4 [-5.25 – 0.44] 0.1
BMI (kg/m2)2 -0.7 [-1.63 – 0.16] 0.11 -0.5 [-1.52 – 0.52] 0.33 -1.0 [-1.89 - -0.03] 0.05
CRP (mg/L)2 14.2 [-4.20 – 32.52] 0.13 8.0 [-13.18 – 29.21] 0.46 18.5 [-0.85 – 37.76] 0.06
AGP (g/L)1* 0.3 [0.005 – 0.59] 0.05 3 0.2 [-0.11 – 0.55] 0.19 0.4 [0.06 – 0.66] 0.02
Neutrophil count (x 109 cells/L)2 0.6 [-0.13 – 1.32] 0.11 0.1 [-0.71 – 0.96] 0.77 0.9 [0.12 – 1.64] 0.02
Lymphocyte count (x 109 cells/L)2 0.2 [-0.16 – 0.49] 0.32 0.3 [-0.08 – 0.67] 0.12 0.1 [-0.26 – 0.42] 0.65
CD4 count (cells/ul)2 -21.2 [-122.66 – 80.36] 0.68 21.9 [-95.47 – 139.35] 0.71 -45.9 [-152.95 – 61.19] 0.40
Hemoglobin (g/dl)2 0.03 [-0.68 – 0.75] 0.93 0.3 [-0.50 – 1.15] 0.44 -0.2 -0.91 – 0.59 0.67
Fasting blood glucose (mmol/L)2 0.1 [-0.32 – 0.51] 0.65 -0.02 [-0.48 – 0.45] 0.95 0.1 [1.71 – 5.08] 0.59
Diabetes (Yes)2 1.5 [0.55 – 4.24] 0.42 1.2 [0.35 – 3.75] 0.81 1.7 [0.60 – 4.97] 0.27
Smoking (Yes)2 2.6 [0.32 – 20.81] 0.38 1.5 [0.54 – 3.97] 0.46 0.9 [0.32 – 2.23] 0.74
TB contact (Yes)2 1.3 0.59 – 2.70 0.55 0.2 [0.50 – 2.90] 0.67 1.2 [0.56 – 2.76] 0.59
BCG scar2 1.5 [0.63 – 3.32] 0.39 1.1 [0.43 – 2.83] 0.83 1.7 [0.69 – 4.13] 0.25
  1. Results are based on a linear and logistic regression models adjusted for age, sex and HIV status.
  2. 1Adjusted for HIV status and gender
  3. 2Adjusted for HIV status, age and gender
  4. 3 P-values <0.05 are in bold.
  5. *HIV negative only
  6. Odds ratio
  7. BMI: Body Mass Index.
  8. EAI: East-African Indian.
  9. CRP: C-reactive protein.
  10. AGP: Orosomucoid.
  11. BCG: Bacillus Calmette-Guerrin.