Figure 1
From: Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment
Cluster plots of selected differentially expressed biomarkers. Cluster plots demonstrate the expression pattern of selected biomarkers between the different groups (HC = healthy controls; 2008-CD + = chagasic samples; 2011-FU = follow-up samples from patients having received treatment with Nfx). Biomarker expression levels in samples treated with Nfx (2011-FU) all return to the levels observed in healthy controls (HC). All biomarkers, except for one, are upregulated during disease (2008-CD+). The downregulated biomarker was previously identified as native human APOA1 (28.1 kDa); the 9.3, 13.6 and 24.7 kDa biomarkers were identified as fragments of human APOA1; and the 28.9 kDa biomarker as a fragment of human FN1.