Figure 5

Model-based projections, 75% vaccine coverage: annual number of cases averted and corresponding number of doses. Left panel: model-based projected reduction in the annual number of MRSA infections due to vaccination at 75% vaccine coverage on top of bundle measures, as a function of the hygiene compliance level for an average case scenario with 50% decolonization and 50% screening. Right panel: annual number of vaccine doses necessary to achieve the corresponding levels of MRSA infection reduction, assuming one dose per patient. All results are shown at steady-state. The slight variations in the number of doses here for the same level of vaccine coverage reflect the corresponding differences in the number of daily admissions, which is allowed to vary in each instance to ensure full hospital occupancy at all times.