TGF beta and IL13 in schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups

Table 2 Comparison of patient characteristics according to the condition of schistosomiasis-associated pulmonary arterial hypertension

Groups	General	With Sch-PAH	Without Sch-PAH	p-value
Samples	68	34	34	-
Age (mean ± sd)	49.3 ± 12.9	49.8 ± 13.2	49.8 ± 12.8	0.759^a
Sex: Male	24 (35.3%)	11 (32.3%)	13 (38.2%)	0.612
Clinical form
Hepatosplenic	64 (94.1%)	30 (88.2%)	34 (100%)	0.039^c
Hepatointestinal	04 (5.9%)	04 (17.8%)	00 (-)
Periportal fibrosis
D^x	24 (35.3%)	13 (38.2%)	11 (32.3%)
E	37 (54.4%)	18 (52.9%)	19 (55.9%)	0.674^c
F	07 (10.3%)	03 (8.9%)	04 (11.8%)	0.685
TGF-β1 pg/ml (median – P₂₅; P₇₅)	19442.2 (11070.4; 30097.2)	22496.9 (15936.7; 32087.8)	13629.9 (10192.2; 22193.8)	0.006^b
IL-13 pg/ml (median – P₂₅; P₇₅)	152.3 (100.2; 165.0)	152.3 (103.7; 177.8)	131.8 (100.2; 162.5)	0.177^b
Portal vein diameter cm	1.15 ± 0.33	1.09 ± 0.37	1.23 ± 0.25	0.085^a
Spleen diameter cm	14.5 ± 3.3	12.7 ± 2.17	16.4 ± 3.3	0.000^a

Recife, 2012.
^aStudent’s t-test; ^bMann–Whitney nonparametric test; ^c Fisher X² test; ^xReference value, D- central fibrosis; E- advanced fibrosis; F- very advanced fibrosis; TGF-β1 – transforming growth factor-beta 1; IL-13- interleukin-13.

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