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Table 3 General discriminate analysis of five marker combinations to discriminate LTBI (QFT + ) and uninfected (QFT - ) household contacts

From: Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

 

QFT negative

QFT positive

   
 

Resubstitution classification

Leave-one-out cross

Resubstitution classification

Leave-one-out cross

Wilks lambda

  

Genes

Matrix

Validation

Matrix

Validation

Value

f

p value

BPI, CASP8, CCL19 and TGFβ1

90.9

81.8

91.6

91.6

0.84

17.45

0.093

BPI, CCL19, FOXP3, TGFβ1 and TIMP2

90.9

81.8

83.3

83.3

0.74

17.67

0.027

CASP8, CCL13, FOXP3 and TGFβ1

81.8

81.8

91.6

91.6

0.86

2.74

0.116

CCL19, CD14, FOXP3, IL2RA and TIMP2

90.9

90.9

83.3

83.3

0.62

10.22

0.005

CASP8, CCL19, FOXP3, RAB24 and TIMP2

81.8

81.8

91.6

91.6

0.92

1.54

0.23

CASP8, CCL19, CD163, FOXP3 and TGFβ1

90.9

81.8

91.6

91.6

0.92

1.53

0.23

CCL19, CD4, FOXP3, IL2RA and TIMP2

90.9

90.9

83.3

83.3

0.63

9.76

0.006

BPI, CCL19, FOXP3, FPR1 and TGFβ1

90.9

90.9

91.6

91.6

0.6

11.08

0.004

CASP8, CCl19, FASL, FOXP3 and TGFβ1

90.9

90.9

83.3

83.3

0.96

0.55

0.46

BPI, CCL19, FOXP3, SEC14L1 and TGFβ1

81.8

81.8

91.6

83.3

0.74

5.85

0.03

  1. Percentage indicates the proportion of groups discriminated using the combination of markers; and f is the measure of fit.