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Table 3 General discriminate analysis of five marker combinations to discriminate LTBI (QFT + ) and uninfected (QFT - ) household contacts

From: Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

  QFT negative QFT positive    
  Resubstitution classification Leave-one-out cross Resubstitution classification Leave-one-out cross Wilks lambda   
Genes Matrix Validation Matrix Validation Value f p value
BPI, CASP8, CCL19 and TGFβ1 90.9 81.8 91.6 91.6 0.84 17.45 0.093
BPI, CCL19, FOXP3, TGFβ1 and TIMP2 90.9 81.8 83.3 83.3 0.74 17.67 0.027
CASP8, CCL13, FOXP3 and TGFβ1 81.8 81.8 91.6 91.6 0.86 2.74 0.116
CCL19, CD14, FOXP3, IL2RA and TIMP2 90.9 90.9 83.3 83.3 0.62 10.22 0.005
CASP8, CCL19, FOXP3, RAB24 and TIMP2 81.8 81.8 91.6 91.6 0.92 1.54 0.23
CASP8, CCL19, CD163, FOXP3 and TGFβ1 90.9 81.8 91.6 91.6 0.92 1.53 0.23
CCL19, CD4, FOXP3, IL2RA and TIMP2 90.9 90.9 83.3 83.3 0.63 9.76 0.006
BPI, CCL19, FOXP3, FPR1 and TGFβ1 90.9 90.9 91.6 91.6 0.6 11.08 0.004
CASP8, CCl19, FASL, FOXP3 and TGFβ1 90.9 90.9 83.3 83.3 0.96 0.55 0.46
BPI, CCL19, FOXP3, SEC14L1 and TGFβ1 81.8 81.8 91.6 83.3 0.74 5.85 0.03
  1. Percentage indicates the proportion of groups discriminated using the combination of markers; and f is the measure of fit.