Table 4 Risk factors for 28-day mortality of candidemia in Shanghai (n=121 episodes)
| Â | 28-day outcome | Mutlivariate analysis | |||
|---|---|---|---|---|---|
| Â | Survival (n=87) | Death (n=34) | P value | OR (95% CI) | P value |
Gender, male [n(%)] | 67 (77.0) | 20 (58.8) | 0.045 | - | 0.25 |
Age (years, Mean±SD) | 55.70±20.71 | 61.38±17.29 | 0.159 | 1.038 (1.007-1.069) | 0.014 |
Underlying disease | Â | Â | Â | Â | Â |
Solid tumor [n(%)] | 15 (17.2) | 11 (32.4) | 0.069 | - | 0.177 |
Hematologic malignancy [n(%)] | 10 (11.5) | 8 (23.5) | 0.094 | - | 0.313 |
Diabetes mellitus [n(%)] | 10 (11.5) | 6 (17.6) | 0.369 | - | - |
Cardiac disease [n(%)] | 26 (29.9) | 6 (17.60 | 0.17 | - | - |
Pulmonary disease [n(%)] | 17 (19.5) | 9 (26.5) | 0.404 | - | - |
Prior surgical intervention (<30 days) [n(%)] | 51 (58.6) | 15 (44.1) | 0.15 | - | 0.806 |
Prior antifungal agents use (<30 days) [n(%)] | 13 (14.9) | 3 (8.8) | 0.372 | - | - |
Corticosteroid use [n(%)] | 13 (14.9) | 7 (20.6) | 0.452 | - | - |
Severity of clinical feature | Â | Â | Â | Â | Â |
Sepsis [n(%)] | 64 (73.6) | 31 (91.2) | 0.034 | - | 0.087 |
Renal replacement therapy [n(%)] | 7 (8.0) | 5 (14.7) | 0.445 | - | - |
Parenteral nutrition [n(%)] | 34 (39.1) | 14 (41.2) | 0.832 | - | - |
Mechanical ventilation [n(%)] | 15 (17.2) | 7 (20.6) | 0.668 | - | - |
Central venous catheter [n(%)] | 68 (78.2) | 27 (79.4) | 0.88 | - | - |
Neutropenia [n(%)] | 5 (5.7) | 9 (26.5) | 0.004 | 17.442 (3.555-85.582) | <0.001 |
Antifungal therapy within 5 days the first blood culture performed | Â | Â | Â | ||
Appropriate empiric therapy | 68 (78.2) | 18 (52.9) | 0.006 | 0.369 (0.146-0.934) | 0.035 |
Inappropriate empiric therapy | 19 (21.8) | 16 (47.1) | Â | Â | Â |