Increase in hippocampal water diffusion and volume during experimental pneumococcal meningitis is aggravated by bacteremia

Table 1 ADC values of ROI covering the hippocampus and the dentate gyrus with corresponding volume changes in hippocampus

	ADC hippocampus	ADC dentate gyrus	Volume (mm³) hippocampus
Uninfected controls	71.6	71.4	12.1
Uninfected controls	[70.0-73.0]	[67.5-74.2]	[11.0-12.9]
Meningitis	82.7	69.6	14.3
Meningitis	[74.7-89.1]*	[65.2-80.7]	[13.2-15.8]*
Meningitis, early onset bacteremia	93.8	72.3	15.8
Meningitis, early onset bacteremia	[80.1-128.7],*	[66.1-82.1]	[13.7-18.1 ],*
Meningitis, attenuated bacteremia	75.7	70.8	11.8
	[71.8-82.2]	[67.5-74.5]	[10.4-14.1]

Data are presented as medians with quartiles.
Measurents of ROI, ADC and volume were performed on 2 coronal slices.
*p < 0.05 compared to the uninfected control group.
**p < 0.05 compared to the attenuated bacteremia group, Kruskal-Wallis test and Dunn’s post test.

ISSN: 1471-2334