The prevalence of opportunistic infections and malignancies in autopsied patients with human immunodeficiency virus infection in Japan

Table 2 Infectious diseases and malignancies in AIDS-associated autopsies

	All patients		ART (−) patients		ART (+) patients
	n	%	n	%	n	%	Pvalues
Total	225	100.0%	136	100.0%	66	100.0%
Infectious diseases
Cytomegalovirus	142	63.1%	97	71.3%	25	37.9%	<0.001
Pneumocystis jirovecii pneumonia	66	29.3%	43	31.6%	11	16.7%	0.024
Non-tuberculous mycobacterium	31	13.8%	20	14.7%	8	12.1%	0.618
Candida	25	11.1%	17	12.5%	6	9.1%	0.474
Aspergillus	24	10.7%	17	12.5%	4	6.1%	0.160
Human immunodeficiency virus encephalopathy	21	9.3%	13	9.6%	6	9.1%	0.915
Cryptococcus	16	7.1%	11	8.1%	3	4.5%	0.526	Y
Hepatitis B virus	12	5.3%	6	4.4%	5	7.6%	0.549	Y
Herpes simplex virus	12	5.3%	1	0.7%	1	1.5%	0.816	Y
Toxoplasmosis	11	4.9%	9	6.6%	3	4.5%	0.789	Y
Hepatitis C virus	9	4.0%	3	2.2%	5	7.6%	0.147	Y
Progressive multifocal leukoencephalopathy	8	3.6%	4	2.9%	2	3.0%	0.684	Y
Tuberculosis	6	2.7%	4	2.9%	0	0.0%	0.385	Y
Varicella zoster virus	4	1.8%	2	1.5%	2	3.0%	0.835	Y
Multicentric Castleman disease	2	0.9%	1	0.7%	1	1.5%	0.816	Y
Malignancies
Non Hodgkin lymphoma	71	31.6%	41	30.1%	25	37.9%	0.272
Kaposi sarcoma	38	16.9%	22	16.2%	10	15.2%	0.852
Endocervical cancer	0	0.0%	0	0.0%	0	0.0%	–
Non-AIDS defining malignancies	20	8.9%	10	7.4%	10	15.2%	0.082
Hepatic cancer	8	3.6%	4	2.9%	4	6.1%	0.495	Y
Lung cancer	6	2.7%	2	1.5%	4	6.1%	0.174	Y
Leukemia	2	0.9%	0	0.0%	2	3.0%	0.200	Y
Hodgkin lymphoma	2	0.9%	1	0.7%	1	1.5%	0.816	Y
Gastric cancer	1	0.4%	1	0.7%	0	0.0%	0.711	Y
Other cancer	3	1.3%	3	2.2%	0	0.0%	0.551	Y

P values were calculated by Chi-square test. Y indicates the use of Chi-square test with Yates correction. Bold font indicates statistical significance. ART, antiretroviral therapy. Because more than one illness was detected in patients, the numbers of all illness are greater than the total number.

ISSN: 1471-2334