Table 3 Monthly drug use density (expressed as RDD per 100 patient days) trends in hematology-oncology (Hem-Onc) and the medical ICU pre- (baseline) and post-intervention as estimated in a single-level interrupted time-series model; only trend changes that were statistically significant are shown
Cephalosporins | Fluorochinolones | Penicillins | TOTAL | ||
|---|---|---|---|---|---|
Baseline trend β1 | Hem-Onc | −0.05 (ns) | −0.18 (<0.001) | −0.00 (ns) | −0.17 (ns) |
Medical ICU | −0.045 (ns) | −0.02 (ns) | −0.49 (<0.001) | −0.31 (ns) | |
Post-intervention | Hem-Onc | −0.41 (<0.001) | −1.16 (<0.001) | +0.17 (ns) | −2.17 (<0.001) |
trend change β2 | Medical ICU | −1.06 (<0.05) | +0.04 (ns) | +1.83 (<0.001) | −1.11 (ns) |
Intercept β0 | Hem-Onc | 14.06 (<0.001) | 38.29 (<0.001) | 18.88 (<0.001) | 124.1 (<0.001) |
Medical ICU | 26.87 (<0.001) | 13.02 (<0.001) | 40.93 (<0.001) | 148.3 (<0.001) | |
N | 63 | 63 | 63 | 63 |