Table 1 Comparison of mean monthly drug use density values expressed as DDD per 100 patient days or RDD per 100 patient days in the medical service pre- and post-intervention
DDD/100 | RDD/100 | |||||||
|---|---|---|---|---|---|---|---|---|
Drug class | Pre- | Post- | Percent change | P value | Pre- | Post- | Percent change | P value |
Cephalosporins | 20.1 | 14.0 | −30.2% | <0.001 | 16.3 | 10.3 | −36.8% | <0.001 |
3° Cephalosporins | 14.4 | 7.4 | −49.0% | <0.001 | 13.1 | 6.4 | −51.3% | <0.001 |
1°/2° Cephalosporins | 5.6 | 6.6 | +17.7% | <0.05 | 3.2 | 3.9 | +23.6% | <0.01 |
Penicillins | 23.1 | 29.6 | +28.3% | <0.001 | 15.4 | 18.2 | +17.9% | <0.001 |
Piperacillin ± BLI | 9.3 | 9.9 | +5.8% | ns | 10.9 | 11.5 | +5.8% | ns |
Aminopenicillins + BLI | 6.6 | 11.3 | +69.9% | <0.001 | 2.4 | 4.1 | +70.4% | <0.001 |
Narrow-spectrum penicillins | 7.1 | 8.5 | +19.1% | ns | 2.1 | 2.5 | +20.3% | ns |
Carbapenems | 9.5 | 8.3 | −12.7% | <0.01 | 6.9 | 5.8 | −15.7% | <0.001 |
Fluoroquinolones | 19.6 | 12.0 | −38.5% | <0.001 | 17.7 | 10.1 | −43.2% | <0.001 |
Aminoglycosides | 0.9 | 0.7 | −18.9% | ns | 0.7 | 0.6 | −19.1% | ns |
Glycopeptides | 4.3 | 3.9 | −8.6% | ns | 4.3 | 3.9 | −8.6% | ns |
Tetracyclines | 1.4 | 0.9 | −36.9% | <0.01 | 1.0 | 0.7 | −35.9% | <0.01 |
Macrolides/clindamycin | 18.1 | 13.7 | −24.4% | <0.001 | 10.3 | 7.9 | −22.8% | 0.001 |
TOTAL | 110.5 | 94.8 | −14.2% | <0.001 | 86.1 | 68.9 | −19.9% | <0.001 |