Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice

BMC Infectious Diseases

Table 1 Amino acid differences among BJ 501, Cal 04 and PR 8 influenza viruses

Gene	Mutation	Effect	Strains*			Reference
Gene	Mutation	Effect	BJ 501	Cal 04	PR8	Reference
PB2	E627K	−627 K associated with increased transmission, advantageous replication at 33°C and confers air transmission of avian virus.	E	E	K	[53]
		-Important determination of host range. Avian strains have 627E, human strains 627 K.
		-627 K is linked to increased virulence in mice.
PA	S224P	Unknown	S	P	S
PA	P275L	Unknown	L	L	P
NS1	P42S	−42S is critical for virulence of H5N1 strains and to antagonize host cell interferon induction	S	S	S
HA	A227E	Unknown	E	E	A
	P83S	Unknown	S	P	P
	A197T	Unknown	A	T	A
	I321V	Unknown	V	I	I
NP	D16G	Unknown	G	G	D
NP	V100I	Unknown	I	V	V
NA	H274Y	-Oseltamivir resistance is associated to H274Y	Y	Y	S
	I106V	Unknown	I	V	I
	D248N	Unknown	D	N	D
M2	S31N	-Confers cross-resistance to adamantane drugs	N	N	N
M1	L42F	Unknown	F	L	L
M1	D94N	Unknown	N	D	D

*BJ501, A/Beijing/501/2009(H1N1); Cal04, A/California/04/2009(H1N1); PR8, A/PR/8/34(H1N1).

ISSN: 1471-2334