Figure 5

Influenza virus-specific CSCs and ASCs responses in the lungs of mice with influenza viruses infection. Influenza virus-specific cytokine secreting cells (CSCs) (A) and antibody secreting cells (ASCs) (B) responses in the lungs of mice with 5 × 10⁵ p.f.u. A/Beijing/501/2009(H1N1) and A/PR/8/34/(H1N1) viruses infection. Quantitative analysis of influenza-specific CSCs (IFN-γ⁺, IL-4⁺ and IL-2⁺) and ASCs (IgG⁺ and IgA⁺) was done with ELISPOT assay. I bars represent standard deviations. The dotted lines were the control level. $ p < 0.05, compared among different time-points within BJ501 viruses infection, # compared among different time-points within PR8 viruses infection, *p < 0.05 and **p < 0.01, compared between BJ501 and PR8 infections at the same time-point.