From: Highly pathogenic avian influenza A virus (H5N1) can be transmitted in ferrets by transfusion
Donors | Recipients | |||||||
---|---|---|---|---|---|---|---|---|
Group | Animal code | Day post- infection | Virus load (fg/ml) (mean ± SD) | Survival (days posttransfusion) | Animal code | Day post- challenge | Virus load (fg/ml) (mean ± SD) | Survival (days posttransfusion) |
Low dose | 51 | 2 | 0a | >12 | 63 | 2,4,8 | 0 | >12 |
6 | 0 | >12 | 67 | 2,4,8 | 0 | >12 | ||
52 | 2 | 0 | >12 | 64 | 2,4,8 | 0 | >12 | |
6 | 0 | >12 | 68 | 2,4,8 | 0 | >12 | ||
53 | 2 | 0 | >12 | 66 | 2,4,8 | 0 | >12 | |
6 | 0 | >12 | 69 | 2,4,8 | 0 | >12 | ||
54 | 4 | 0 | >12 | 70 | 2 | 8.12 × 104 ± 5.17 × 102 | 6 | |
4 | 5.77 × 105 ± 6.90 × 103 | |||||||
6 | 4.02 × 106 ± 3.94 × 105 | |||||||
10 | 0 | >12 | 73 | 2,4,8 | 0 | >12 | ||
55 | 4 | 0 | >12 | 71 | 2,4,8 | 0 | >12 | |
10 | 7.62 × 104 ± 1.31 × 103 | >12 | 74 | 2,4,8 | 0 | >12 | ||
56 | 4 | 0 | >12 | 72 | 2,4,8 | 0 | >12 | |
10 | 0 | >12 | 75 | 4 | 1.33 × 104 ± 9.59 × 103 | >12 | ||
High dose | 57 | 2 | 0 | 7 | 76 | 2,4,8 | 0 | >12 |
6 | 4.94 × 105 ± 5.27 × 104 | 79 | 8 | 2.11 × 104 ± 4.23 × 103 | >12 | |||
58 | 2 | 0 | >12 | 77 | 2,4,8 | 0 | >12 | |
6 | 0 | 80 | 2,4,8 | 0 | >12 | |||
59 | 2 | 7.62 × 104 ± 3.57 × 103 | 6 | 78 | 2 | 2.30 × 106 ± 2.58 × 104 | 4 | |
6 | 1.93 × 106 ± 6.95 × 105 | 81 | 2 | 2.01 × 104 ± 1.60 × 103 | 5 | |||
4 | 8.59 × 104 ± 5.63 × 103 | |||||||
60 | 4 | 0 | 7 | 82 | 2 | 4.51 × 106 ± 9.65 × 104 | 4 | |
7 | 2.12 × 105 ± 2.35 × 104 | 85 | 2 | 5.81 × 105 ± 3.65 × 104 | 7 | |||
4 | 1.18 × 107 ± 5.99 × 105 | |||||||
61 | 4 | 0 | 8 | 83 | 2,4,8 | 0 | >12 | |
8 | 2.28 × 106 ± 5.94 × 105 | 86 | 4 | 4.79 × 104 ± 2.54 × 103 | 11 | |||
62 | 4 | 5.10 × 104 ± 2.37 × 103 | 8 | 84 | 2 | 9.76 × 104 ± 3.14 × 103 | 5 | |
4 | 1.67 × 107 ± 5.96 × 105 | |||||||
8 | 1.33 × 104 ± 6.59 × 102 | 87 | 2,4,8 | 0 | >12 | |||
PBS | 49 | 4 | 0 | 88 | 8 | 0 | >12 | |
50 | 6 | 0 | 89 | 8 | 0 | >12 | ||
62 | 10 | 0 | 90 | 8 | 0 | >12 |