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Table 3 Viral load (fg/ml) in blood of ferrets (donors) infected with H5N1 virus, A/VN/1203/04 and the ferrets (recipients) transfused with blood from their appropriate donors using the RT-qPCR

From: Highly pathogenic avian influenza A virus (H5N1) can be transmitted in ferrets by transfusion

Donors

Recipients

Group

Animal code

Day post- infection

Virus load (fg/ml) (mean ± SD)

Survival (days posttransfusion)

Animal code

Day post- challenge

Virus load (fg/ml) (mean ± SD)

Survival (days posttransfusion)

Low dose

51

2

0a

>12

63

2,4,8

0

>12

  

6

0

>12

67

2,4,8

0

>12

 

52

2

0

>12

64

2,4,8

0

>12

  

6

0

>12

68

2,4,8

0

>12

 

53

2

0

>12

66

2,4,8

0

>12

  

6

0

>12

69

2,4,8

0

>12

 

54

4

0

>12

70

2

8.12 × 104 ± 5.17 × 102

6

      

4

5.77 × 105 ± 6.90 × 103

 
      

6

4.02 × 106 ± 3.94 × 105

 
  

10

0

>12

73

2,4,8

0

>12

 

55

4

0

>12

71

2,4,8

0

>12

  

10

7.62 × 104 ± 1.31 × 103

>12

74

2,4,8

0

>12

 

56

4

0

>12

72

2,4,8

0

>12

  

10

0

>12

75

4

1.33 × 104 ± 9.59 × 103

>12

High dose

57

2

0

7

76

2,4,8

0

>12

  

6

4.94 × 105 ± 5.27 × 104

 

79

8

2.11 × 104 ± 4.23 × 103

>12

 

58

2

0

>12

77

2,4,8

0

>12

  

6

0

 

80

2,4,8

0

>12

 

59

2

7.62 × 104 ± 3.57 × 103

6

78

2

2.30 × 106 ± 2.58 × 104

4

  

6

1.93 × 106 ± 6.95 × 105

 

81

2

2.01 × 104 ± 1.60 × 103

5

      

4

8.59 × 104 ± 5.63 × 103

 
 

60

4

0

7

82

2

4.51 × 106 ± 9.65 × 104

4

  

7

2.12 × 105 ± 2.35 × 104

 

85

2

5.81 × 105 ± 3.65 × 104

7

      

4

1.18 × 107 ± 5.99 × 105

 
 

61

4

0

8

83

2,4,8

0

>12

  

8

2.28 × 106 ± 5.94 × 105

 

86

4

4.79 × 104 ± 2.54 × 103

11

 

62

4

5.10 × 104 ± 2.37 × 103

8

84

2

9.76 × 104 ± 3.14 × 103

5

      

4

1.67 × 107 ± 5.96 × 105

 
  

8

1.33 × 104 ± 6.59 × 102

 

87

2,4,8

0

>12

PBS

49

4

0

 

88

8

0

>12

 

50

6

0

 

89

8

0

>12

 

62

10

0

 

90

8

0

>12

  1. Note: a) 0 indicates that viral load could not be detectable in our experiment condition.