Table 1 Baseline characteristics and clinical outcomes of ATTAIN study patients with Staphylococcus aureus nosocomial pneumonia according to vancomycin trough levels
Vancomycin trough level (μg/mL), n (%)* | p† | |||
|---|---|---|---|---|
< 10 (n = 30) | 10 to < 15 (n = 33) | ≥ 15 (n = 35) | ||
Age (mean ± SD, year) | 60 ± 20 | 69 ± 13 | 69 ± 14 | 0.14 |
APACHE II score (mean ± SD) | 16 ± 5 | 17 ± 7 | 18 ± 6 | 0.45 |
Creatinine clearance ≤ 50 mL/min | 10 (33) | 18 (55) | 14 (40) | 0.22 |
Acute renal failure | 2 (7) | 5 (15) | 10 (29) | 0.06 |
Multilobar pneumonia | 17 (57) | 19 (58) | 28 (80) | 0.08 |
Bacteremia‡ | 6 (20) | 2 (6) | 2 (6) | 0.10 |
Resident in ICU | 20 (67) | 24 (73) | 28 (80) | 0.48 |
Use of vasopressor/inotropic | 5 (17) | 5 (15) | 7 (20) | 0.87 |
Shock | 2 (7) | 2 (6) | 4 (11) | 0.68 |
Potentially nephrotoxic prior antibiotic therapy | ||||
Vancomycin | 11 (37) | 14 (42) | 17 (49) | 0.63 |
Amikacin | 1 (3) | 1 (3) | 2 (6) | -- |
Gentamicin | 0 | 2 (6) | 1 (3) | -- |
Prior antibiotic failure | 11 (37) | 18 (55) | 28 (80) | 0.002 |
MRSA | 20 (67) | 26 (79) | 30 (86) | 0.18 |
Staphylococcus aureus MIC > 1 μg/mL | 0 | 0 | 1 (3) | 0.41 |