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Table 3 Factors associated with HIV positive persons developing (single measurement) eGFR of <60 ml/min/1.73 m 2 who had baseline eGFR > 90 /ml/min1.73/m 2

From: Higher risk of renal impairment associated with tenofovir use amongst people living with HIV in India: A comparative cohort analysis between Western India and United Kingdom

   Univariate Multivariate
   HR 95% CI p HR 95% CI p
Centre Pune 4.87 2.28, 10.38 <0.0001 7.65 3.36, 17.41 <.0001
  RF 1.00 -   1.00 -  
Age Per 10 years older 1.85 1.43, 2.40 <.00001 2.21 1.61, 3.05 <.0001
Gender Female 1.63 0.89, 2.99 0.12 1.72 0.90, 3.29 0.10
  Male 1.00 -   1.00 -  
Receiving PI Yes 1.01 0.57, 1.79 0.97 2.40 1.21, 4.76 0.01
  No 1.00 -   1.00 -  
CD4 count Per 100 cells 1.01 0.90, 1.13 0.89 1.04 0.89, 1.20 0.65
Time since diagnosis Per year longer 0.98 0.92, 1.04 0.46 1.00 0.92, 1.07 0.92
CD4 nadir Per 100 cells 0.94 0.78, 1.14 0.55 0.99 0.79, 1.23 0.91
Ever received a PI before TDF Yes 0.76 0.32, 1.78 0.52 0.77 0.28, 2.15 0.62
  No 1.00 -   1.00 -