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Table 7 Positive predictive values of Crossing point (Cp) values with different cut-off limits for detection of severe sepsis/septic shock, for blood samples with a positive SeptiFast test for Gram-negative bacteria

From: Quantitative data from the SeptiFast real-time PCR is associated with disease severity in patients with sepsis

Cut-off Cp value Escherichia coli(n = 33) Klebsiella pneumoniae/oxytoca(n = 13) Gram-negative bacteria, other* (n = 11) Gram-negative bacteria total (n = 57)
<15.0 100% (3/3) 100% (1/1) 0% (0/1) 80% (4/5)
<17.5 100% (5/5) 100% (2/2) 0% (0/1) 88% (7/8)
<20.0 37% (5/11) 100% (2/2) 0% (0/2) 47% (7/15)
<22.5 30% (7/23) 29% (2/7) 20% (1/5) 29% (10/35)
<25.0 30% (8/27) 22% (2/9) 33% (3/9) 29% (13/45)
>25 24% (8/33) 15% (2/13) 27% (3/11) 23% (13/57)
  1. For samples that were positive for Gram-negative bacteria with Cp >25 (n = 12) the result is presented as >25 by the software, and not with continuous variables.
  2. Data is presented as percentages (No. of SeptiFast positive samples from patients with severe sepsis /No. of SeptiFast positive samples in total, according to cut-off).
  3. *Including: Enterobacter cloacae (n = 5), Pseudomonas aeruginosa (n = 5), and Serratia marcescens (n = 1).
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