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Table 2 Hemagglutination inhibition-based immunogenicity in the per-protocol immunogenicity cohort

From: Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults

Vaccine Sample time-point SCR/booster SCR SPR
n/N; % (95% CI) n/N; % (95% CI)
   Primary strain Booster strain Primary strain Booster strain
AS03 A -H5N1 Day 0 15/933; 1.6 1/933; 0.1
    (0.9, 2.6) (0.0, 0.6)
Day 21 393/925; 42.5 24/925; 2.6 412/925; 44.5 27/925; 2.9
  (39.3, 45.7) (1.7, 3.8) (41.3, 47.8) (1.9, 4.2)
Day 42 866/924; 93.7 464/924; 50.2 871/924; 94.3 464/924; 50.2
   (92.0, 95.2) (46.9, 53.5) (92.6, 95.7) (46.9, 53.5)
Heterologous booster Month 6 103/251; 41.0 9/251; 3.6
    (34.9, 47.4) (1.7, 6.7)
Month 6 + 21 233/256; 91.0 241/256; 94.1 242/251; 96.4 238/251; 94.8
   (86.8, 94.2) (90.5, 96.7) (93.3, 98.3) (91.3, 97.2)
Non-adjuvanted-H5N1 Day 0 5/236; 2.1 0/236; 0.0
    (0.7, 4.9) (0.0, 1.6)
Day 21 8/234; 3.4 0/234; 0.0 16/234; 6.8 0/234; 0.0
  (1.5, 6.6) (0.0, 1.6) (4.0, 10.9) (0.0, 1.6)
Day 42 13/234; 5.6 1/234; 0.4 24/234; 10.3 1/234; 0.4
   (3.0, 9.3) (0.0, 2.4) (6.7, 14.9) (0.0, 2.4)
Heterologous booster Month 6 4/224; 1.8 0/224; 0.0
    (0.5, 4.5) (0.0, 1.6)
Month 6 + 21 112/228; 49.1 106/228; 46.5 120/223; 53.8 105/223; 47.1
  (42.5, 55.8) (39.9, 53.2) (47.0, 60.5) (40.4, 53.9)
Month 6 + 42 173/228; 75.9 189/228; 82.9 180/228; 78.9 189/228; 82.9
   (69.8, 81.3) (77.4, 87.5) (73.1, 84.1) (77.4, 87.5)
  1. CI, Confidence Interval; n/N, number of subjects fulfilling criteria for defined outcome/total number of subjects in group; SCR, seroconversion rates defined as percentage of subjects achieving an increase in HI titers from <1:10 to ≥1:40 or at least a 4-fold post-vaccination increase in HI titer from a pre-vaccination titer ≥1:10; Booster SCR was SCR based on increases in HI antibody titers from pre-vaccination titers at Month 6; SPR, seroprotection rate defined as the percentage of subjects with HI titers ≥1:40 following vaccination; primary vaccine strain, H5N1/A/Vietnam/1194/2004; booster strain H5N1/A/Indonesia/5/2005.