Table 4 Hemagglutination-inhibition antibody responses after TIV in the per-protocol immunogenicity cohort
Strain | Time point | Seropositive | GMT | MGI | |||
|---|---|---|---|---|---|---|---|
n (%; 95% CI) | value (95% CI) | value (95% CI) | |||||
18–60 years | >60 years | 18–60 years | >60 years | 18–60 years | >60 years | ||
N = 49 | N = 70 | N = 49 | N = 70 | N = 49 | N = 70 | ||
A/H1N1 | Day 0 | 35 | 37 | 39.2 | 15.2 | – | – |
(71.4; 56.7–83.4) | (52.9; 40.6–64.9) | (24.0–63.8) | (11.1–21.0) | ||||
Day 21 | 49 | 70 | 390.1 | 142.1 | 10.0 (6.3–15.7) | 9.3 (6.8–12.8) | |
(100; 92.7–100) | (100; 94.9–100) | (293.8–518.1) | (105.1–192.0) | ||||
A/H3N2 | Day 0 | 26 | 38 | 14.1 | 13.0 | – | – |
(53.1; 38.3–67.5) | (54.3; 41.9–66.3) | (10.1–19.8) | (9.8–17.3) | ||||
Day 21 | 49 | 70 | 185.6 | 183.7 | 13.1 (9.3–18.5) | 14.1 (10.2–19.5) | |
(100; 92.7–100) | (100; 94.9–100) | (140.9–244.5) | (139.6–241.8) | ||||
B strain (Victoria) | Day 0 | 34 | 58 | 22.7 | 28.0 | – | – |
(69.4; 54.6–81.7) | (82.9; 72.0–90.8) | (15.2–34.0) | (21.5–36.5) | ||||
Day 21 | 48 | 69 | 260.6 | 248.6 | 11.5 (7.0–18.7) | 8.9 (6.3–12.4) | |
(98.0; 89.1–99.9) | (98.6; 92.3–100) | (184.6–368.0) | (185.9–332.3) | ||||