|
Strain
|
Time point
|
Seropositive
|
GMT
|
MGI
|
|---|
|
n (%; 95% CI)
|
value (95% CI)
|
value (95% CI)
|
|---|
|
18–60 years
|
>60 years
|
18–60 years
|
>60 years
|
18–60 years
|
>60 years
|
|---|
|
N = 49
|
N = 70
|
N = 49
|
N = 70
|
N = 49
|
N = 70
|
|---|
|
A/H1N1
|
Day 0
|
35
|
37
|
39.2
|
15.2
|
–
|
–
|
|
(71.4; 56.7–83.4)
|
(52.9; 40.6–64.9)
|
(24.0–63.8)
|
(11.1–21.0)
|
|
Day 21
|
49
|
70
|
390.1
|
142.1
|
10.0 (6.3–15.7)
|
9.3 (6.8–12.8)
|
|
(100; 92.7–100)
|
(100; 94.9–100)
|
(293.8–518.1)
|
(105.1–192.0)
|
|
A/H3N2
|
Day 0
|
26
|
38
|
14.1
|
13.0
|
–
|
–
|
|
(53.1; 38.3–67.5)
|
(54.3; 41.9–66.3)
|
(10.1–19.8)
|
(9.8–17.3)
|
|
Day 21
|
49
|
70
|
185.6
|
183.7
|
13.1 (9.3–18.5)
|
14.1 (10.2–19.5)
|
|
(100; 92.7–100)
|
(100; 94.9–100)
|
(140.9–244.5)
|
(139.6–241.8)
|
|
B strain (Victoria)
|
Day 0
|
34
|
58
|
22.7
|
28.0
|
–
|
–
|
|
(69.4; 54.6–81.7)
|
(82.9; 72.0–90.8)
|
(15.2–34.0)
|
(21.5–36.5)
|
|
Day 21
|
48
|
69
|
260.6
|
248.6
|
11.5 (7.0–18.7)
|
8.9 (6.3–12.4)
|
|
(98.0; 89.1–99.9)
|
(98.6; 92.3–100)
|
(184.6–368.0)
|
(185.9–332.3)
|
- TIV, inactivated trivalent influenza vaccine; Seropositive, titer ≥1:10; GMT, geometric mean titer; MGI, mean geometric increase defined as the geometric mean of the ratio between pre-vaccination and post-vaccination reciprocal titers.
