Amino acid sequence alignment of the full length VP1 region of the EV71 virus isolates in Linyi City, Shandong Province, 2010. Amino acid sequences were numbered according to the sequence of EV71_BrCr (Genbank accession number: ETU22521). Identical residues are indicated as dots. Amino acids that differ from the consensus sequence are shaded. ▲, isolates of severe cases.