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Table 2 Changes from M0 to M24 in plasma markers of inflammation and immune activation (log e -transformed values)

From: Comparative impact of antiretroviral drugs on markers of inflammation and immune activation during the first two years of effective therapy for HIV-1 infection: an observational study

   Total n = 78 TDF/ FTC n = 61 ABC/ 3TC n = 17 EFV n = 36 ATV/r n = 27 LPV/r n = 15
IL-6 Baseline (pg/ml) 1.6 (1.1-2.5) 1.6 (1.1-2.6) 1.2 (0.99-1.7) 1.6 (1.1-2.5) 1.2 (0.88-2.4) 2.17 (1.1-7.4)
Mean fold change (95% CI) 0.60 (0.49, 0.74) 0.60 (0.48, 0.77) 0.60 (0.36, 0.99) 0.59 (0.42, 0.83) 0.82 (0.64, 1.05) 0.36 (0.20, 0.67)
P value* <0.001      
hs-CRP Baseline (mg/L) 4 (2.2-15) 4.2 (2.3-15) 2.7 (1.8-9.4) 3.9 (2.2-17.8) 3 (2-5.9) 7.5 (2.9-20)
Mean fold change (95% CI) 0.77 (0.57, 1.1) 0.81 (0.56, 1.20) 0.66 (0.33, 1.30) 0.76 (0.46, 1.26) 0.88 (0.54, 1.44) 0.63 (0.27, 1.47)
P value 0.11      
sCD14 Baseline (106 pg/ml) 2.6 (2.1-3.1) 2.6 (2.2-3.1) 2.5 (2-3.1) 2.5 (2.2-3) 2.6 (1.7-3.1) 3.1 (2-3.4)
Mean fold change (95% CI) 1.00 (0.93, 1.1) 1.00 (0.93, 1.10) 0.96 (0.79, 1.15) 0.95 (0.85, 1.06) 1.10 (0.93, 1.26) 1.00 (0.85, 1.20)
P value 0.82      
IP-10 Baseline (pg/ml) 664 (431-960) 630 (435-974) 721 (431-895) 692 (447-996) 549 (389-781) 798 (470-1326)
Mean fold change (95% CI) 0.41 (0.35, 0.49) 0.44 (0.36, 0.52) 0.37 (0.27, 0.49) 0.34 (0.28, 0.42) 0.53 (0.40, 0.71) 0.43 (0.27, 0.67)
P value <0.001      
MIG Baseline (pg/ml) 1532 (980-2804) 1534 (1004-2804) 1431 (938-2562) 1908 (1093-3799) 1182 (920-2201) 1611 (887-2444)
Mean fold change (95% CI) 0.26 (0.19, 0.33) 0.25 (0.18, 0.35) 0.27 (0.17, 0.42) 0.16 (0.10, 0.24) 0.39 (0.30, 0.51) 0.39 (0.22, 0.70)
  P value <0.001      
  1. TDF, Tenofovir; FTC, Emtricitabine; ABC, Abacavir; 3TC, Lamivudine; EFV, Efavirenz; ATV/r, Atazanavir/ritonavir; LPV/r, Lopinavir/ritonavir; IL-6, Interleukin-6; hs-CRP, Highly sensitive C-reactive protein; sCD14, soluble CD14; 1P10, Interferon-γ-Inducible Protein 10; MIG, Monokine induced by interferon-γ; CI, Confidence Interval.
  2. *One-sample Student’s t test of the change of each marker in the overall study sample.
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