Skip to content


BMC Infectious Diseases

Open Access

Pneumococcal meningitis: analysis of the cases admitted in the last year in the intensive care unit of the National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest

  • Andrei Rogoz1Email author,
  • Cleo Roşculeț1,
  • Ana-Maria Petrescu1,
  • Cătălin Apostolescu1,
  • Monica Ivan1,
  • Marius Radu1,
  • Aida Răşcanu1,
  • Alina Frangulea1,
  • Monica Ungureanu1,
  • Mihaela Tudor1,
  • Bogdan Pavel1 and
  • Doina Iovănescu1
BMC Infectious Diseases201313(Suppl 1):P99

Published: 16 December 2013


Invasive pneumococcal infections are still associated with significant morbidity and mortality. The objective of this work is to emphasize the correct therapeutic approach in pneumococcal meningoencephalitis.


We retrospectively analyzed a series of patients admitted in the National Institute for Infectious Diseases “Prof. Dr. Matei Balş” Intensive Care Unit (ICU) between September 2012 and September 2013, regarding the underlying diseases, clinical and biological features, the treatment, the complications and the outcome. We reviewed the antimicrobial guidelines regarding the pneumococcal invasive infections.


In one year interval there were 7 cases of severe pneumococcal meningoencephalitis admitted in Matei Balş ICU, Adults Department. All the pneumococcal strains identified were penicillin sensitive. Despite broad antibiotic coverage, after admission, the evolution was severe and the mortality rate was around 70%. Delayed hospital presentation and/or diagnosis explained the majority of the therapeutic failures.


Proper treatment of the entities that can lead to pneumococcal meningoencephalitis (as ENT infections), prompt recognition of the first symptoms and rapid accurate treatment offer the best chance of a good outcome.

Authors’ Affiliations

National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest, Romania


© Rogoz et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.