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BMC Infectious Diseases

Open Access

Management of brain abscesses in children

  • Gheorghiță Jugulete1, 2Email author,
  • Monica Luminos1, 2,
  • Anca Drăgănescu1,
  • Magdalena Vasile1,
  • Angelica Vişan1, 2,
  • Mădălina Maria Merişescu1, 2,
  • Anuța Bilaşco1,
  • Camelia Kouris1,
  • Endis Osman1,
  • Sabina Șchiopu1,
  • Adrian Iliescu3 and
  • Virgil Ionescu4
BMC Infectious Diseases201313(Suppl 1):P98

Published: 16 December 2013


Bacterial brain abscess is an important cause of morbidity and mortality both in adults and in children. Usually, abscesses are secondary to congenital malformations or are complications of improperly treated infections. Rarely, abscesses appear without an apparent predisposing cause in a good state of health.


We performed a retrospective study on cases of bacterial brain abscesses admitted in the Pediatric Intensive Care Unit of the National Institute for Infectious Diseases “Prof. Dr. Matei Balş” between 01 January 2008 and 01 January 2013. We monitored age, gender, predisposing factors, comorbidities, onset, treatment, evolution and complications.


In the aforementioned period we registered 12 cases of bacterial brain abscesses in children.

The female gender and the 8 to 14 age group have prevailed. 50% of cases presented a congenital heart defect, 25% untreated bacterial infections, 12.5% a history of craniocerebral injury and 12.5% presented no evident predisposing cause.

The onset consisted of: fever, vomiting, nausea, seizures, neurological problems. All of the cases required emergency neurosurgical treatment and specific antibiotherapy. Before the etiology of the infection was established, patients received empiric broad spectrum antibiotherapy (meropenem and linezolid), with subsequent antibiotic de-escalation over the next 6 weeks. The treatment was monitored clinically, biologically and with imaging studies. The evolution was favorable in all cases. No deaths were registered. Neurological sequelae were present in 41.7% of the cases: hemiparesis, sight and speech problems, psycho-motor impairment, seizures.


Careful monitoring of predisposing factors of brain abscesses is important for this severe condition which can result in permanent sequelae or death.

Authors’ Affiliations

National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest, Romania
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Clinical and Emergency Hospital “Prof. Dr. Bagdasar Arseni”, Bucharest, Romania
Provita – Center of Diagnosis and Treatment Bucharest, Romania


© Jugulete et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.