Volume 13 Supplement 1

Proceedings of the 9th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof Dr Matei Bals”

Open Access

Correlations between noninvasive tests as predictors of liver fibrosis and of viral response in chronic hepatitis C patients

  • Oana Streinu-Cercel1, 2Email author,
  • Elena-Sînziana Daia2, 3,
  • Mihail Tiberiu Daia2,
  • Anca Streinu-Cercel1, 2,
  • Tania Gudu3 and
  • Adrian Streinu-Cercel1, 2
BMC Infectious Diseases201313(Suppl 1):P54

https://doi.org/10.1186/1471-2334-13-S1-P54

Published: 16 December 2013

Background

The noninvasive assessment of liver fibrosis in chronic hepatitis C patients is very important as it dictates the disease prognosis and the indication for therapy, narrowing down the use of the liver biopsy. Standardized scores (FibroTest, FibroMax) and imaging techniques (FibroScan) have been validated in this respect. As for the noninvasive prediction of the sustained viral response (SVR), GenoFibroTest and Prometheus are two indexes that may be used. This study's aim is to compare several biological scores with these standardized scores for evaluating fibrosis and the two indexes for prediction of SVR.

Methods

We performed a cross-sectional analysis on a group of patients with chronic hepatitis C evaluated at the National Institute for Infectious Diseases “Prof. Dr. Matei Balş”. We assessed serum tests, FibroScan, FibroTest and IL28B polymorphism. We calculated several biological scores (APRI, Lok, Forn’s, FIB-4 and Bonacini) and compared them with each other and with FibroScan/FibroTest and we calculated and compared the GenoFibroTest and Prometheus indexes, verifying the statistic correlation of the results.

Results

The study included 56 patients (of which 26 were males); the median age was 52±12 years. The median necroinflammatory activity was 0.58±0.25, as evaluated through ActiTest. The median FibroTest values were 0.55±0.30 while the median FibroScan scores were 8.8±9.7 kPa. The areas under the receiver operating characteristic (AUROC) for APRI, Lok, Forn’s, FIB-4, Bonacini scores and FibroScan, compared to FibroTest were 0.70, 0.78, 0.85, 0.80, 0.78 and 0.71 respectively, for F≥2; and 0.83, 0.79, 0.92, 0.86, 0.77 and 0.77, respectively, for F=4. As for the prediction of SVR, for a cut-off of GenoFibroTest of 0.4, Prometheus index’s AUROC was 0.85.

Conclusion

All the evaluated scores had excellent predictive value, with Forn’s being the best biological score, especially for the assessment of significant fibrosis (F2-F4). Prometheus index had a good predictive value of the patients that could benefit only from double therapy, in the context of the triple association. If more non-invasive tests could be standardized, the stage of fibrosis and the SVR could be easily estimated, and the need for biopsy could be narrowed down.

Declarations

Acknowledgement

This paper is partly supported by the Sectoral Operational Programme Human Resources Development (SOP HRD) 2007-2013, financed from the European Social Fund and by the Romanian Government under the contract number POSDRU/107/1.5/S/82839.

Authors’ Affiliations

(1)
National Institute for Infectious Diseases “Prof. Dr. Matei Balş”
(2)
Carol Davila University of Medicine and Pharmacy
(3)
Internal Medicine and Rheumatology Department, “Sf. Maria” Clinical Hospital

Copyright

© Streinu-Cercel et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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