Volume 13 Supplement 1

Proceedings of the 9th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof Dr Matei Bals”

Open Access

Dialysis peritonitis in a patient with chronic kidney disease and multiple comorbidities

  • Oana Streinu-Cercel1, 2Email author,
  • Anca Streinu-Cercel1, 2,
  • Ioana Berciu1, 2,
  • Alina Cristina Neguț1, 2,
  • Mihai Săndulescu1,
  • Maria Magdalena Moțoi2 and
  • Adrian Streinu-Cercel1, 2
BMC Infectious Diseases201313(Suppl 1):P34

https://doi.org/10.1186/1471-2334-13-S1-P34

Published: 16 December 2013

Background

Patients with peritoneal catheters are at risk for developing infections with germs with altered antibiotic sensitivity, being classified as Carmeli 3 due to repeated invasive contact with the hospital system. A cloudy peritoneal fluid is oftentimes a sentinel sign of infection and medical and surgical management are generally required to clear infection and prevent subsequent reoccurrences.

Case report

We report the case of a 70 year-old male patient, with chronic kidney disease under peritoneal dialysis, type II diabetes mellitus, cardiac insufficiency, arterial hypertension, dyslipidemia, bilateral carotid atheromatosis, grade 1 obesity, COPD, and history of repeated peritonitis, including a previous episode of sepsis with MSOF.

The presenting complaint, dating back two weeks, consisted of lower abdominal pain followed by two unformed stools; 12 hours later the dialysis fluid turned cloudy; 24 hours later the patient was admitted to a Nephrology Clinic. In the tenth day of symptomatology, the patient became drowsy and was transferred to our clinic, for infectious diseases management.

Clinical exam at admission revealed: mediocre clinical state, bilateral leg and dorsal hand edema, arterial tension 140/90 mmHg, pulse 80 bpm, abdomen distended through peritoneal dialysis, hepatomegaly.

Lab results showed inflammatory syndrome, slight anemia, nitrogen retention syndrome.

Peritoneal fluid cultures grew Rothia mucilaginosa and the patient mentioned recent dentist treatment with full-mouth prosthetic rehabilitation. We performed a complete dental exam and cultures from: gingival sulcus fluid, dental plaque, tongue; results came out positive for Enterococcus faecalis and Candida spp and peritoneal fluid cultures grew Candida lipolytica. Over the course of hospital admission, the peritoneal count rose to over 4000 cells/cmm, and the patient presented fever, chills, obnubilation.

Under treatment with meropenem, linezolid, voriconazole and peritoneal instillations with vancomycin, the patient’s evolution was favorable.

Due to the isolation of Candida lipolytica, together with the nephrologist and the surgeon, on the 23rd day of evolution a subclavian hemodialysis catheter was placed and on the 25th day, the peritoneal catheter was removed (cultures positive for Candida lipolytica). For the long term management of the kidney disease, a hemodialysis fistula was performed.

Conclusion

The clinical evolution corroborated the initial suspicion of dialysis peritonitis of mixed etiology, fungal and Rothia spp. Close interdisciplinary collaboration between the infectious disease specialist and the nephrologist is mandatory in order to conduct a proper treatment.

Authors’ Affiliations

(1)
Carol Davila University of Medicine and Pharmacy
(2)
National Institute for Infectious Diseases “Prof. Dr. Matei Balş”

Copyright

© Streinu-Cercel et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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