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Seasonal and age-related variations impacting HPV vaccination uptake in Romania


We report data regarding the influence of seasonal factors and patient age on the uptake of HPV vaccination in Romania, following the introduction of the vaccine in the national immunization schedule.


We prospectively collected data regarding the national immunization schedule between June 2010 and June 2013. For this report, we analyzed the impact of age and seasonal variations on the number of vaccines administered monthly.


In the studied time span 80,509 HPV vaccine doses were administered in Romania, 46% (37,359) of these representing the third and final dose of the vaccination regimen. By the end of June 2013, 38,281 women of all ages had completed the full 3-dose HPV vaccination regimen.

The studied time span appears to show a biphasic evolution of the vaccination schedule: between June 2010 and August 2011, absolute numbers were constantly above 1,500 doses per month, while after August 2011 there was an important decrease, with the total number of shots per months constantly below 1,000 but above 150.

The months with the lowest numbers reported were April (2,787), June (2,196) and July (1,649) 2011 in the first time span and September (250), October (245) 2011, September 2012 (186), February (227) and March (205) 2013 for the second time span.

The number of girls undergoing vaccination during June-December 2010 was higher in the lower age groups, with 10,456 girls in the 12-14 years old age group, 13,135 (15-19 years old), 15,723 (20-24 years old), 10,785 (age 24 and over). After 2011, the proportions changed, with the largest numbers of vaccines being administered at increasingly higher ages: 1,671 (12-14 years old), 4,737 (15-19 years old), 8,152 (20-24 years old), 9,800 (age 24 and over) during 2011; 319 (12-14 years old), 598 (15-19 years old), 1,585 (20-24 years old), 1,821 (age 24 and over) during 2012 and 120 (12-14 years old), 215 (15-19 years old), 518 (20-24 years old), 874 (age 24 and over) during January-June 2013.


Romania has recorded an interesting shift from the initial school vaccination campaigns to the more recent uptake of vaccine in women of all ages.

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Correspondence to Oana Streinu-Cercel.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Streinu-Cercel, O., Streinu-Cercel, A., Rafila, A. et al. Seasonal and age-related variations impacting HPV vaccination uptake in Romania. BMC Infect Dis 13 (Suppl 1), P28 (2013).

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