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BMC Infectious Diseases

Open Access

Acute liver failure related to hepatitis B (a four-case series)

  • Andrei Rogoz1Email author,
  • Cleo Roşculeț1,
  • Cătălin Apostolescu1,
  • Monica Ivan1,
  • Marius Radu1,
  • Aida Răşcanu1,
  • Alina Frangulea1,
  • Monica Ungureanu1,
  • Mihaela Tudor1,
  • Bogdan Pavel1 and
  • Doina Iovănescu1
BMC Infectious Diseases201313(Suppl 1):P100

Published: 16 December 2013


Acute liver failure related to hepatitis B infection may occur after acute HBV infection or during an exacerbation (flare) of a chronic HBV infection. The condition is associated with a very high morbidity and mortality rate.

Case report

We present the diagnosis and management difficulties of a four-case series admitted to our clinic during the last year, with severe acute liver failure, with encephalopathy that required medical management, intensive care and organ support, including artificial extracorporeal liver support.


In the presence of acute liver failure and serological evidence of hepatitis B viral infection, differentiating between acute infection and exacerbation (flare) of chronic infections remains a challenge. Mortality rates remain high inspite of recent medical advance.

Authors’ Affiliations

National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest, Romania


© Rogoz et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.