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  • Oral presentation
  • Open Access

Lung infections in cardiac transplant recipients

  • 1, 2Email author,
  • 1, 2,
  • 1, 2,
  • 1, 2,
  • 3 and
  • 2, 4
BMC Infectious Diseases201313 (Suppl 1) :O26

  • Published:


  • Tacrolimus
  • Transplant Recipient
  • Aspergillosis
  • Pulmonary Infection
  • Pulmonary Tuberculosis


Lung infections represent the most common cause of mortality and morbidity in heart transplant recipients. The most important factors which determine the prevalence and type of infection in this category of patients are those related to type, regimen and length of immunosuppressive treatment.

The objectives of this study involve the assessment of the prevalence of pulmonary infections and the impact of the antibacterial, antiviral prophylactic treatment on the onset of different lung infections, following heart transplantation.


Over the course of 48 months, we monitored 37 consecutive patients with cardiac transplant. Immunosuppressive therapy (cyclosporine, tacrolimus and prednisone) was administered. Post-transplant pulmonary infections were monitored. The etiological diagnosis (bacterial, viral, fungal and parasitic) was determined through the following methods: bacteriology, serum serology, sputum samples, bronchial biopsy, chest X-ray or chest CT scan respectively.


The mean age was 39 (range: 12 to 59 years). There were 28 male (75.7%) and 9 female (24.3%) patients. During the first 6 months following the transplant, 12 patients developed viral pneumonia, 6 bacterial pneumonia, 3 pulmonary aspergillosis, 2 pulmonary tuberculosis. During the study, a total of 58 cases of respiratory infections were recorded, with a rate of 1.5 episodes per patient.


Different Gram positive and Gram negative bacterial infections, mainly community acquired, did not result in severe complications compared to fungal and specific infections which had a lethal outcome.

Authors’ Affiliations

Infectious Disease Clinic I, Tîrgu Mureş County Clinic Hospital, Romania
University of Medicine and Pharmacy, Tîrgu Mureş, Romania
Cardiology Clinic 2, Institute of Cardiovascular Diseases and Transplantation Tîrgu Mureş, Romania
Cardiac Rehabilitation Clinic, Tîrgu Mureş Emergency County Clinic Hospital, Romania


© Ţilea et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.