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Open Access

In the era of broad spectrum antibiotics, is ampicillin still an option?

  • Cristina Popescu1, 2Email author,
  • Gabriel-Adrian Popescu1, 2,
  • Alina Lobodan1,
  • Raluca Dulama1,
  • Doina Niculescu1,
  • Diana Tănase1,
  • Mihaela Rădulescu1, 2,
  • Violeta Molagic1,
  • Cătălin Tilişcan1, 2,
  • Liliana Ion1,
  • Mirela Cernat1,
  • Mirela Dinu1,
  • Iulia Caragea1,
  • Angelica Teniță1,
  • Georgiana Juganaru1,
  • Elisabeta Benea1, 2 and
  • Victoria Aramă1, 2
BMC Infectious Diseases201313(Suppl 1):O14

Published: 16 December 2013


MeningitisAmpicillinSevere SepsisDiverticulitisBroad Spectrum Antibiotic


In the era of broad spectrum antibiotics it is sometimes difficult to choose the best antimicrobial regimens. Because of misuse and abuse of antimicrobial usage, the level of resistance is increasing and sometimes we do not have treatment options. Infectious diseases specialists traditionally have the leadership role in optimal use of antimicrobials. Antimicrobial stewardship represents a worldwide accepted concept in order to preserve currently available antibiotics.

Case report

We present 4 cases of severe sepsis with known etiology successfully treated with ampicillin. The first patient was diagnosed with enterococcal spondylodiscitis related to colon diverticulitis. The second patient was a pregnant woman who developed listeriosis. The third patient was diagnosed with pneumococcal meningitis and the forth patient was diagnosed with bacteremic pneumococcal pneumonia. We chose ampicillin because of its narrow antimicrobial spectrum, among therapeutic alternatives. A cost efficiency analysis was performed for each patient.


We emphasize the importance of microbiological diagnosis in order to use de-escalation. Ampicillin remains a very good option in severe infections produced by sensitive germs.

Authors’ Affiliations

National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest, Romania
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania


© Popescu et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.