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Table 1 Isolates from IPD in children from Germany from July 1997 to June 2011, proportion of serotype 19A and antibiotic resistance among serotype 19A isolates

From: Epidemiology of serotype 19A isolates from invasive pneumococcal disease in German children

  Number of isolates per season Number of serotype Number of 19A isolates resistant* (%)
Season 19A (%) PEN I+R CLA R CLI R TET R MDR
Pre-PCV vaccination period
1997-1998 167 7 (4.2) 1 (14.3) 1 (14.3) 0 (0.0) 1 (14.3) 0 (0.0)
1998-1999 152 6 (3.9) 2 (33.3) 1 (16.7) 1 (16.7) 1 (16.7) 1 (16.7)
1999-2000 190 6 (3.2) 1 (16.7) 2 (33.3) 2 (33.3) 3 (50.0) 2 (33.3)
2000-2001 238 5 (2.1) 0 (0.0) 1 (20.0) 1 (20.0) 1 (20.0) 1 (20.0)
2001-2002 241 7 (2.9) 3 (42.9) 1 (14.3) 1 (14.3) 2 (28.6) 1 (14.3)
2002-2003 239 4 (1.7) 0 (0.0) 1 (25.0) 1 (25.0) 0 (0.0) 1 (25.0)
2003-2004 272 6 (2.2) 2 (33.3) 1 (16.7) 1 (16.7) 1 (16.7) 0 (0.0)
2004-2005 286 11 (3.8) 5 (45.5) 4 (36.4) 3 (27.3) 5 (45.5) 2 (18.2)
2005-2006 291 6 (2.1) 2 (33.3) 2 (33.3) 1 (16.7) 4 (66.7) 1 (16.7)
Total 2076 58 (2.8#) 16 (27.6) 14 (24.1) 11 (19.0) 18 (31.0) 9 (15.5)
Post-PCV vaccination period (PCV7)
2006-2007 295 12 (4.1) 3 (25.0) 5 (41.7) 5 (41.7) 6 (50.0) 5 (41.7)
2007-2008 241 11 (4.6) 4 (36.4) 2 (18.2) 1 (9.1) 4 (36.4) 1 (9.1)
2008-2009 249 19 (7.6) 12 (63.2) 5 (26.3) 4 (21.1) 8 (42.1) 5 (26.3)
Post-PCV vaccination period (PCV10, PCV7/13)
2009-2010 233 24 (10.3) 11 (45.8) 7 (29.2) 7 (29.2) 6 (25.0) 7 (29.2)
2010-2011 234 35 (15.0) 8 (22.9) 8 (22.9) 8 (22.9) 7 (20.0) 8 (22.9)
Total (post PCV) 1252 101 (9.9#) 38 (37.6) 27 (26.7) 25 (24.8) 31 (30.7) 26 (25.7)
  1. #The Fisher’s exact two-tailed P values are ≤0.001.
  2. The two-sampled t-test exact two-tailed P values are ≤0.05.
  3. *PEN penicillin; CLA clarithromycin; CLI clindamycin; TET tetracycline; R resistant, I intermediately resistant'; MDR multidrug-resistant.