Prevalence of enteroviruses in children with and without hand, foot, and mouth disease in China

BMC Infectious Diseases

Table 2 Prevalences of enterovirus serotypes in children with and without hand, foot, and mouth disease

	HFMD cases		Healthy children (n = 254)	P value^b
	Severe HFMD	Mild HFMD		Severe HFMD vs. mild HFMD	HFMD cases vs. healthy children
	(n = 151)	(n = 428)		Severe HFMD vs. mild HFMD	HFMD cases vs. healthy children
HEV status
Negative	27 (17.9)	112 (26.2)	195 (76.8)	0.04	< 0.001
Positive	124 (82.1)	316 (73.8)	59 (23.2)
HEV serotypes^a
EV71	83 (55.0)	170 (39.7)	38 (15.0)	0.001	< 0.001
CVA16	18 (11.9)	86 (20.0)	7 (2.8)	0.024	< 0.001
CVA10	11 (7.3)	22 (5.1)	2 (0.8)	0.33	0.001
CVA6	4 (2.7)	18 (4.2)	4 (1.6)	0.39	0.09
E3	0	1 (0.2)	2 (0.8)	ND	0.17
E9	2 (1.3)	1 (0.2)	1 (0.4)	0.11	0.81
E24	0	1 (0.2)	1 (0.4)	ND	0.55
CVB6	0	2 (0.5)	1 (0.4)	ND	0.91
E6	1 (0.7)	1 (0.2)	0	0.44	ND
CVA12	2 (1.3)	4 (0.9)	0	0.68	ND
CVA4	0	1 (0.2)	0	ND	ND
CVA14	1 (0.7)	0	0	ND	ND
Untyped	2 (1.3)	9 (2.1)	3 (1.2)	ND	ND

^aHFMD, hand, foot, and mouth disease; EV, enterovirus; CV, coxsackievirus; E, echovirus; NA; ND, not determined.
^bFisher exact test or χ ² test.

ISSN: 1471-2334