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Table 9 Multivariate stepwise binary logistic regression analysis between CCC and ASY including as covariates the gender and the polymorphisms associated in all the previous multivariate analysis

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

Step Covariates Groups Association test
Step1 Gender Male vs Female p = 0.001; OR = 2.179; 95% CI: 1.36-3.49
  CCR5rs3176763 CC vs CA + AA p = 0.014; OR = 1.763; 95% CI: 1.12-2.77
  TIRAP rs8177376 AA vs AC + CC p = 0.014; OR = 1.363; 95% CI: 1.07-1.74
  TIRAP rs17866704 TT vs TC + CC p = 0.048; OR = 1.291; 95% CI: 1.01-1.66
  CCL2rs2530797 AA vs AG + GG p = 0.114; OR = 1.212; 95% CI: 1.04-1.54
  TIRAP rs8177376 AA vs AC + CC p = 0.014; OR = 1.363; 95% CI: 1.07-1.74
Step2 Gender Male vs Female p = 0.001; OR = 2.179; 95% CI: 1.36-3.48
  CCR5rs3176763 CC vs CA + AA p = 0.008; OR = 1.842; 95% CI: 1.17-2.88
  TIRAP rs8177376 AA vs AC + CC p = 0.015; OR = 1.356; 95% CI: 1.06-1.73
  TIRAP rs17866704 TT vs TC + CC p = 0.064; OR = 1.267; 95% CI: 1.01-1.63
  CCL2rs2530797 AA vs AG + GG Excluded
Step3 Gender Male vs Female p = 0.001; OR = 2.226; 95% CI: 1.39-3.55
  CCR5rs3176763 CC vs CA + AA p = 0.007; OR = 1.879; 95% CI: 1.19-1.89
  TIRAP rs8177376 AA vs AC + CC p = 0.007; OR = 1.393; 95% CI: 1.09-1.77
  TIRAP rs17866704 TT vs TC + CC Excluded
  CCL2rs2530797 AA vs AG + GG Excluded