Table 9 Multivariate stepwise binary logistic regression analysis between CCC and ASY including as covariates the gender and the polymorphisms associated in all the previous multivariate analysis
Step | Covariates | Groups | Association test |
|---|---|---|---|
Step1 | Gender | Male vs Female | p = 0.001; OR = 2.179; 95% CI: 1.36-3.49 |
|  | CCR5rs3176763 | CC vs CA + AA | p = 0.014; OR = 1.763; 95% CI: 1.12-2.77 |
|  | TIRAP rs8177376 | AA vs AC + CC | p = 0.014; OR = 1.363; 95% CI: 1.07-1.74 |
|  | TIRAP rs17866704 | TT vs TC + CC | p = 0.048; OR = 1.291; 95% CI: 1.01-1.66 |
|  | CCL2rs2530797 | AA vs AG + GG | p = 0.114; OR = 1.212; 95% CI: 1.04-1.54 |
|  | TIRAP rs8177376 | AA vs AC + CC | p = 0.014; OR = 1.363; 95% CI: 1.07-1.74 |
Step2 | Gender | Male vs Female | p = 0.001; OR = 2.179; 95% CI: 1.36-3.48 |
|  | CCR5rs3176763 | CC vs CA + AA | p = 0.008; OR = 1.842; 95% CI: 1.17-2.88 |
|  | TIRAP rs8177376 | AA vs AC + CC | p = 0.015; OR = 1.356; 95% CI: 1.06-1.73 |
|  | TIRAP rs17866704 | TT vs TC + CC | p = 0.064; OR = 1.267; 95% CI: 1.01-1.63 |
|  | CCL2rs2530797 | AA vs AG + GG | Excluded |
Step3 | Gender | Male vs Female | p = 0.001; OR = 2.226; 95% CI: 1.39-3.55 |
|  | CCR5rs3176763 | CC vs CA + AA | p = 0.007; OR = 1.879; 95% CI: 1.19-1.89 |
|  | TIRAP rs8177376 | AA vs AC + CC | p = 0.007; OR = 1.393; 95% CI: 1.09-1.77 |
|  | TIRAP rs17866704 | TT vs TC + CC | Excluded |
|  | CCL2rs2530797 | AA vs AG + GG | Excluded |