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Table 5 Genotype distribution on controls (ASY individuals) and cases (CCC) taking into account the gender and the left ventricular ejection fraction values

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

    ASY CCC CCC (EF ≤ 0.4) CCC (EF ≥ 0.4)
Gene SNP Genotype  Total  Male Female  Total  Male Female  Total  Male Female  Total  Male Female
CCR5 rs3176763 CC 110 50 59 266 167 97 169 127 42 88 34 54
(94.0%) (96.2%) (92.2%) (84.4%) (87.0%) (80.2%) (84.9%) (88.2%) (76.4%) (89.0%) (81.0%) (84.4%)
   CA 7 2 5 48 25 23 30 17 13 17 8 9
(6.0%) (3.8%) (7.8%) (15.2%) (13.0%) (19.0%) (15.1%) (11.8%) (23.6%) (16.0%) (19.0%) (14.1%)
   AA 0 0 0 1 0 1 0 0 0 1 0 1
(0.0%) (0.0%) (0.0%) (0.3%) (0.0%) (0.8%) (0.0%) (0.0%) (0.0%) (0.9%) (0.0%) (1.6%)
CCR5 rs3087253 AA 46 18 28 134 81 52 80 61 19 52 20 32
(41.4%) (36.7%) (45.9%) (43.9%) (43.5%) (44.4%) (41.0%) (43.3%) (35.2%) (51.0%) (50.0%) (51.6%)
   AG 47 22 24 119 73 46 80 52 28 34 16 18
(42.3%) (44.9%) (39.3%) (39.0%) (39.2%) (39.3%) (41.0%) (36.9%) (51.9%) (33.3%) (40.0%) (29.0%)
   GG 18 9 9 52 32 19 35 28 7 16 4 12
(16.2%) (18.4%) (14.8%) (17.0%) (17.2%) (16.2%) (17.9%) (19.9%) (13.0%) (15.7%) (10.0%) (19.4%)
CCR5 rs11575815 AA 51 25 25 158 97 60 104 74 22 51 22 29
(45.1%) (49.0%) (41.0%) (51.3%) (51.6%) (50.8%) (52.8%) (52.1%) (53.7%) (50.0%) (53.7%) (47.5%)
   AT 42 20 22 120 70 49 71 50 16 43 16 27
(37.2%) (39.2%) (36.1%) (39.0%) (37.2%) (41.5%) (36.0%) (35.2%) (39.0%) (42.2%) (39.0%) (44.3%)
   TT 20 6 14 30 21 9 22 18 3 8 3 5
(17.7%) (11.8%) (23.0%) (9.7%) (11.2%) (7.6%) (11.2%) (12.7%) (7.3%) (7.8%) (7.3%) (8.2%)
CCL2 rs3760396 GG 87 41 45 247 152 94 153 112 41 87 36 51
(75.7%) (80.4%) (71.4%) (79.9%) (80.9%) (79.0%) (77.7%) (78.9%) (74.5%) (85.3%) (90.0%) (82.3%)
   GC 27 9 18 60 35 24 43 29 14 14 4 10
(23.5%) (17.6%) (28.6%) (19.4%) (18.6%) (20.2%) (21.8%) (20.4%) (25.5%) (13.7%) (10.0%) (16.1%)
   CC 1 1 0 2 1 1 1 1 0 1 0 1
(0.9%) (2.0%) (0.0%) (0.6%) (0.5%) (0.8%) (0.5%) (0.7%) (0.0%) (1.0%) (0.0%) (1.6%)
CCL2 rs2857656 CC 50 24 25 122 70 50 77 52 25 42 17 25
(44.2%) (48.0%) (40.3%) (39.7%) (37.6%) (42.0%) (39.3%) (36.9%) (45.5%) (41.2%) (42.5%) (40.3%)
   CG 51 22 29 150 92 58 96 72 24 51 18 33
(45.1%) (44.0%) (46.8%) (48.9%) (49.5%) (48.7%) (49.0%) (51.1%) (43.6%) (50.0%) (45.0%) (53.2%)
   GG 12 4 8 35 24 11 23 17 6 9 5 4
(10.6%) (8.0%) (12.9%) (11.4%) (12.9%) (9.2%) (11.7%) (12.1%) (10.9%) (8.8%) (12.5%) (6.5%)
CCL2 rs4586 TT 38 20 18 74 41 32 46 31 15 26 9 17
(34.5%) (40.8%) (30.0%) (24.0%) (21.7%) (27.4%) (23.4%) (21.8%) (27.3%) (25.5%) (22.0%) (27.9%)
   TC 53 23 29 148 90 57 94 70 24 52 19 33
(48.2%) (49.9%) (48.3%) (48.1%) (47.6%) (48.7%) (47.7%) (49.3%) (43.6%) (51.0%) (46.3%) (54.1%)
   CC 19 6 13 86 58 28 57 41 16 26 13 11
(17.3%) (12.2%) (21.7%) (27.9%) (30.7%) (23.9%) (28.9%) (28.9%) (29.1%) (25.5%) (31.7%) (18.0%)
CCL2 rs3917891 CC 107 47 59 264 161 101 166 120 46 91 37 54
(93.9%) (90.4%) (96.7%) (86.0%) (86.1%) (85.6%) (85.6%) (85.7%) (85.2%) (88.3%) (90.2%) (87.1%)
   CT 7 5 2 41 25 16 26 19 7 12 4 8
(6.1%) (9.6%) (3.3%) (13.4%) (13.4%) (13.6%) (13.4%) (13.6%) (13.0%) (11.7%) (9.9%) (12.9%)
   TT 0 0 0 2 1 1 2 1 1 0 0 0
(0.0%) (0.0%) (0.0%) (0.7%) (0.5%) (0.8%) (1.0%) (0.7%) (1.9%) (0.0%) (0.0%) (0.0%)
CCL2 rs2530797 AA 47 13 33 163 104 58 110 81 29 47 19 28
(41.6%) (25.5%) (54.1%) (52.9%) (55.6%) (48.7%) (55.8%) (57.0%) (52.7%) (45.6%) (47.5%) (44.4%)
   AG 52 33 19 115 68 46 69 51 18 44 16 28
(46.0%) (64.7%) (31.1%) (37.3%) (36.4%) (38.7%) (35%) (35.9%) (32.7%) (42.7%) (40%) (44.4%)
   GG 14 5 9 30 15 15 18 10 8 12 5 7
(12.4%) (9.8%) (14.8%) (9.7%) (8.0%) (12.6%) (9.1%) (7.0%) (14.5%) (11.7%) (12.5%) (11.1%)
CCL2 rs991804 CC 51 25 25 120 67 51 78 52 26 40 15 25
(45.5%) (48.1% (42.4%) (41.2%) (38.3%) (44.7%) (42.6%) (39.4%) (51.0%) (40.4%) (39.5%) (41.0%)
   CT 53 24 29 148 92 56 88 67 21 54 20 34
(47.3%) (46.2%) (49.2%) (50.9%) (52.6%) (51.1%) (48.1%) (50.8%) (41.2%) (54.5%) (52.6%) (55.7%)
   TT 8 3 5 23 16 7 17 13 4 5 3 2
(7.1%) (5.8%) (8.5%) (7.9%) (9.1%) (6.1%) (9.3%) (9.8%) (7.8%) (5.1%) (7.9%) (3.3%)
TIRAP rs11220437 TT 92 44 47 229 142 85 146 106 40 74 31 43
(80.0%) (84.6%) (75.8%) (73.9%) (74.7%) (72.0%) (73.7%) (73.6%) (74.1%) (71.8%) (75.6%) (69.4%)
   TC 22 8 14 76 45 31 48 36 12 28 9 19
(19.1%) (15.4%) (22.6%) (24.5%) (23.7%) (26.3%) (24.2%) (25.0%) (22.2%) (27.2%) (22.0%) (30.6%)
   CC 1 0 1 5 3 2 4 2 2 1 1 0
(9.0%) (0.0%) (1.6%) (1.6%) (1.6%) (1.7%) (2.0%) (1.4%) (3.7%) (1.0%) (2.4%) (0.0%)
TIRAP rs591163 GG 51 23 28 158 95 82 104 74 20 52 30 32
(46.4%) (46.9%) (46.7%) (51.5%) (50.5%) (53.0%) (53.1%) (52.1%) (50.0%) (51.5%) (55.6%) (52.5%)
   GA 44 19 24 120 76 43 75 56 16 38 19 22
(40.0%) (38.8%) (40.0%) (39.1%) (40.4%) (36.8%) (38.3%) (39.4%) (40.0%) (37.6%) (35.2%) (36.1%)
   AA 15 7 8 29 17 12 17 12 4 11 5 7
(13.6%) (14.3%) (13.3%) (9.4%) (9.0%) (10.3%) (8.7%) (8.5%) (10.0%) (10.9%) (9.3%) (11.5%)
TIRAP rs8177352 AA 83 38 44 225 132 91 140 98 42 80 31 49
(73.5%) (4.5%) (72.1%) (73.3%) (70.6%) (77.1%) (71.4%) (69.5%) (76.4%) (77.7%) (75.6%) (79.0%)
   AG 28 12 16 73 48 25 47 36 11 23 10 13
(24.8%) (23.5%) (26.2%) (23.8%) (25.7%) (21.2%) (24.0%) (25.5%) (20.0%) (22.3%) (24.4%) (21.0%)
   GG 2 60 1 9 7 2 9 7 2 0 0 0
(1.8%) (23.5%) (1.6%) (2.9%) (3.7%) (1.7%) (4.6%) (5.0%) (3.6%) (0.0%) (0.0%) (0.0%)
TIRAP rs8177375 AA 95 45 49 246 153 91 156 115 41 82 34 48
(84.1%) (88.2%) (80.3%) (79.4%) (81.4%) (75.8%) (79.2%) (81.0%) (74.5%) (78.8%) (82.9%) (76.2%)
   AG 16 5 11 60 33 27 39 26 13 20 6 14
(14.2%) (9.8%) (18.0%) (19.4%) (17.6%) (22.5%) (19.8%) (18.3%) (23.6%) (19.2%) (14.6%) (22.2%)
   GG 2 1 1 4 2 2 2 1 1 2 1 1
(1.8%) (2.0%) (1.6%) (1.2%) (1.0%) (1.7%) (1.0%) (0.7%) (1.8%) (1.9%) (2.4%) (1.6%)
TIRAP rs8177376 AA 63 26 37 230 143 85 149 110 39 74 29 45
(54.9%) (57.8%) (60.7%) (75.4%) (77.7%) (71.4%) (76.8%) (79.1%) (70.9%) (71.8%) (72.5%) (71.4%)
   AC 40 18 22 70 40 30 44 28 16 25 11 14
(37.7%) (40.0%) (36.1%) (23.0%) (21.7%) (25.2%) (22.7%) (20.1%) (29.1%) (24.3%) (27.5%) (22.2%)
   CC 3 1 2 5 1 4 1 1 0 4 0 4
(2.8%) (2.2%) (3.3%) (1.6%) (0.5%) (3.4%) (0.5%) (0.7%) (0.0%) (3.9%) (0.0%) (6.3%)
TIRAP rs17866704 TT 80 35 44 175 103 71 115 80 35 54 20 34
(70.8%) (70.0%) (71.0%) (57.4%) (55.4%) (60.7%) (59.0%) (56.7%) (64.8%) (53.5%) (50.0%) (55.7%)
   TC 32 15 17 106 64 41 63 46 17 40 16 24
(28.3%) (30.0%) (27.4%) (34.8%) (34.4%) (35.0%) (32.3%) (32.6%) (31.5%) (39.6%) (40%) (39.3%)
   CC 1 0 1 24 19 5 17 15 2 7 4 3
(0.9%) (0.0%) (1.6%) (7.9%) (10.2%) (4.3%) (8.7%) (10.6%) (3.7%) (6.9%) (10.0%) (4.9%)