Skip to main content

Advertisement

Table 1 Univariate analysis of covariates including patient drug exposures, comorbidities, and the association with hospitalized SSSTI

From: “Serious skin & soft tissue infections in rheumatoid arthritis patients taking anti-tumor necrosis factor alpha drugs: a nested case–control study”

Variable Case Control Odds Ratio 95% P-Value
N = 97 N = 291 Confidence Interval  
Frequency (Percent) Frequency (Percent)
MEDICATONS      
Anti-TNF Drugs      
Biologics 90 days before index date 19 (19.59) 53 (18.15) 1.107 0.604, 2.028 0.74
Biologics Anytime Before Index 29 (29.90) 70 (23.97) 1.388 0.815, 2.363 0.23
ETANERCEPT Anytime Before Index 16 (16.49) 42 (14.38) 1.184 0.631, 2.22 0.60
INFLIXIMAB IV Anytime Before Index 3 (3.09) 13 (4.45) 0.857 0.178, 4.126 0.85
ADALIMUMAB Anytime Before Index 1 (1.03) 7 (2.40) 0.404 0.47, 3.462 0.41
Monoclonals Only: INFLIXIMAB/ ADALIMUMAB 7 (7.22) 14 (4.79) 0.633 0.178, 2.245 0.48
Concomitant Medications      
Methotrexate within 30 days of index date 20 (20.62) 89 (30.48) 0.578 0.325, 1.029 0.06
Prednisone within 30 days of index date 51 (52.58) 107 (36.64) 1.921 1.206, 3.058 <0.01
Prednisone 6 mo. prior to index date 56 (57.73) 144 (49.32) 1.447 0.898, 2.334 0.13
Azathioprine within 30 days of index date 3 (3.09) 4 (1.37) 2.250 0.504, 10.053 0.29
Leflunomide within 30 days of index date 7 (7.22) 25 (8.56) 0.819 0.345, 1.940 0.65
Hydroxychlorquine within 30 days of index date 23 (23.71) 84 (28.77) 0.784 0.462, 1.330 0.36
Sulfasalazine within 30 days of index date 6 (6.19) 38 (13.01) 0.454 0.187, 1.104 0.08
Antibiotic use 90 days prior to index date 86 (88.66) 51 (17.47) 44.984 16.41, 123.28 <0.01
Concomitant Inflammatory Diseases      
Psoriasis 10 (10.31) 33 (11.30) 0.892 0.411, 1.934 0.77
Crohns 3 (3.09) 3 (3.09) 2.805 0. 564, 13.962 0.21
Ulcerative Colitis 3 (3.09) 4 (1.37) 2.121 0.473, 9.514 0.33
Ankylosing Spondylitis 4 (4.12) 7 (2.40) 1.714 0.502, 5.86 0.39
Uveitis 2 (2.06) 0 (0.00) 0.138 - ∞, 0.573 0.13
Co-morbidities      
Diabetes mellitus 36 (37.11) 53 (18.15) 2.514 1.528, 4.134 <0.01
Chronic Kidney Disease 15 (15.46) 11 (3.77) 4.558 1.981, 10.487 <0.01
Neoplasm 9 (9.28) 12 (4.11) 2.464 0.993, 6.116 0.50
Chronic Bronchitis 44 (45.36) 81 (27.74) 2.133 1.327, 3.429 0.01
Gastroesophageal Reflux 36 (37.11) 94 (32.19) 1.282 0.777, 2.114 0.33
HIV 0 (0.00) 1 (0.34) 0.333 0.009, ∞ 1.00
Prior History of Skin Infection (SSSTI) 26 (26.80) 17 (5.82) 5.729 2.870, 11.434 <0.01
Discharge 3 Months Prior 14 (14.43) 20 (6.85) 2.245 1.098, 4.590 0.03
Chronic Liver Disease 2 (2.06) 0 (0.00) 0.167 -∞, 0.7732 0.17
Other Bacterial Infections      
Pneumonia 4 (4.12) 1 (0.34) 12 1.341, 107.63 0.03
Septic Arthritis 1 (1.03) 1 (1.03) .333 0.004, 26.166 0.89
  1. Cell count less than 5, Exact Analysis Used.