Table 4 The association of TLR9 and IFNG SNPs with the development of pulmonary tuberculosis
Genotype | PTB patients, n (%) | LTBI controls n (%) | Adjusted OR* (95% CI) p value | Adjusted OR&(95% CI) p value | PTB patients n (%) | Healthy controls without MTB infection n (%) | Adjusted OR* (95% CI) p value | Adjusted OR&(95% CI) p value | |
|---|---|---|---|---|---|---|---|---|---|
TLR9 1174 A/G (rs352139) | AA | 70 (35.0) | 67 (34.0) | Ref. | Ref. | 70 (35.0) | 68 (34.7) | Ref. | Ref. |
AG | 89 (44.5) | 106 (53.8) | 0.80 (0.52-1.25)p = 0.325 | 0.74 (0.44-1.25) p = 0.264 | 89 (44.5) | 95 (48.5) | 0.91 (0.58-1.41) p = 0.668 | 0.67 (0.39-1.15) p = 0.149 | |
GG | 41 (20.5) | 24 (12.2) | 1.64 (0.19-3.01) p = 0.110 | 1.72 (0.81-3.64) p = 0.155 | 41 (20.5) | 33 (16.8) | 1.21 (0.69-2.13) p = 0.511 | 0.98 (0.49-1.96) p = 0.953 | |
Dominant | GG + AG vs AA | 0.96 (0.63-1.45) p = 0.833 | 0.90 (0.55-1.48) p = 0.687 | 0.99 (0.65-1.49) p = 0.949 | 0.75 (0.45-1.24) p = 0.263 | ||||
Recessive | GG vs AG + AA | 1.87 (1.08-3.23) p = 0.027 | 2.04 (1.02-4.06) p = 0.043 | 1.28 (0.77-2.13) p = 0.346 | 1.22 (0.65-2.27) p = 0.536 | ||||
TLR9 1635 A/G (rs352140) | GG | 72 (36.0) | 70 (35.5) | Ref. | Ref. | 72 (36.0) | 71 (36.2) | Ref. | Ref. |
GA | 88 (44.0) | 104 (52.8) | 0.82 (0.53-1.27) p = 0.377 | 0.80 (0.47-1.34) p = 0.391 | 88 (44.0) | 93 (37.5) | 0.93 (0.60-1.45) p = 0.749 | 0.72 (0.42-1.23) p = 0.223 | |
AA | 40 (20.0) | 23 (11.7) | 1.70 (0.92-3.12) p = 0.091 | 1.74 (0.82-3.69) p = 0.152 | 40 (20.0) | 32 (16.3) | 1.24 (0.70-2.18) p = 0.468 | 1.00 (0.50-2.00) p = 1.00 | |
Dominant | AA + GA vs GG | 0.98 (0.65-1.48) p = 0.920 | 0.95 (0.58-1.56) p = 0.839 | 1.01 (0.67-1.52) p = 0.964 | 0.79 (0.48-1.30) p = 0.353 | ||||
Recessive | AA vs GA + GG | 1.90 (1.09-3.31) p = 0.025 | 1.97 (0.98-3.96) p = 0.057 | 1.29 (0.77-2.15) p = 0.341 | 1.20 (0.64-2.45) p = 0.579 | ||||
IFNG 2109 G/A (rs1861494) | AA | 74 (37.0) | 57 (28.9) | Ref. | Ref. | 74 (37.0) | 73 (37.2) | Ref. | Ref. |
AG | 97 (48.5) | 99 (50.3) | 0.75 (0.48-1.18) p = 0.212 | 0.57 (0.33-0.99) p = 0.045 | 97 (48.5) | 85 (43.4) | 1.13 (0.73-1.74) p = 0.591 | 1.22 (0.71-2.07) p = 0.470 | |
GG | 29 (14.5) | 41 (20.8) | 0.54 (0.30-0.98) p = 0.042 | 0.44 (0.21-0.91) p = 0.027 | 29 (14.5) | 38 (19.4) | 0.75 (0.42-1.34) p = 0.334 | 0.74 (0.37-1.51) p = 0.413 | |
Dominant | GG + AG vs AA | 0.69 (0.45-1.06) p = 0.087 | 0.53 (0.32-0.90) p = 0.018 | 1.01 (0.67-1.52) p = 0.960 | 1.06 (0.65-1.74) p = 0.814 | ||||
Recessive | GG vs AG + AA | 0.65 (0.38-1.09) p = 0.100 | 0.62 (0.33-1.18) p = 0.145 | 0.70 (0.41-1.20) p = 0.194 | 0.67 (0.35-1.28) p = 0.228 | ||||