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Table 4 The association of TLR9 and IFNG SNPs with the development of pulmonary tuberculosis

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

Genotype PTB patients, n (%) LTBI controls n (%) Adjusted OR* (95% CI) p value Adjusted OR&(95% CI) p value PTB patients n (%) Healthy controls without MTB infection n (%) Adjusted OR* (95% CI) p value Adjusted OR&(95% CI) p value
TLR9 1174 A/G (rs352139) AA 70 (35.0) 67 (34.0) Ref. Ref. 70 (35.0) 68 (34.7) Ref. Ref.
AG 89 (44.5) 106 (53.8) 0.80 (0.52-1.25)p = 0.325 0.74 (0.44-1.25) p = 0.264 89 (44.5) 95 (48.5) 0.91 (0.58-1.41) p = 0.668 0.67 (0.39-1.15) p = 0.149
GG 41 (20.5) 24 (12.2) 1.64 (0.19-3.01) p = 0.110 1.72 (0.81-3.64) p = 0.155 41 (20.5) 33 (16.8) 1.21 (0.69-2.13) p = 0.511 0.98 (0.49-1.96) p = 0.953
Dominant GG + AG vs AA 0.96 (0.63-1.45) p = 0.833 0.90 (0.55-1.48) p = 0.687    0.99 (0.65-1.49) p = 0.949 0.75 (0.45-1.24) p = 0.263
Recessive GG vs AG + AA 1.87 (1.08-3.23) p = 0.027 2.04 (1.02-4.06) p = 0.043    1.28 (0.77-2.13) p = 0.346 1.22 (0.65-2.27) p = 0.536
TLR9 1635 A/G (rs352140) GG 72 (36.0) 70 (35.5) Ref. Ref. 72 (36.0) 71 (36.2) Ref. Ref.
GA 88 (44.0) 104 (52.8) 0.82 (0.53-1.27) p = 0.377 0.80 (0.47-1.34) p = 0.391 88 (44.0) 93 (37.5) 0.93 (0.60-1.45) p = 0.749 0.72 (0.42-1.23) p = 0.223
AA 40 (20.0) 23 (11.7) 1.70 (0.92-3.12) p = 0.091 1.74 (0.82-3.69) p = 0.152 40 (20.0) 32 (16.3) 1.24 (0.70-2.18) p = 0.468 1.00 (0.50-2.00) p = 1.00
Dominant AA + GA vs GG 0.98 (0.65-1.48) p = 0.920 0.95 (0.58-1.56) p = 0.839    1.01 (0.67-1.52) p = 0.964 0.79 (0.48-1.30) p = 0.353
Recessive AA vs GA + GG 1.90 (1.09-3.31) p = 0.025 1.97 (0.98-3.96) p = 0.057    1.29 (0.77-2.15) p = 0.341 1.20 (0.64-2.45) p = 0.579
IFNG 2109 G/A (rs1861494) AA 74 (37.0) 57 (28.9) Ref. Ref. 74 (37.0) 73 (37.2) Ref. Ref.
AG 97 (48.5) 99 (50.3) 0.75 (0.48-1.18) p = 0.212 0.57 (0.33-0.99) p = 0.045 97 (48.5) 85 (43.4) 1.13 (0.73-1.74) p = 0.591 1.22 (0.71-2.07) p = 0.470
GG 29 (14.5) 41 (20.8) 0.54 (0.30-0.98) p = 0.042 0.44 (0.21-0.91) p = 0.027 29 (14.5) 38 (19.4) 0.75 (0.42-1.34) p = 0.334 0.74 (0.37-1.51) p = 0.413
Dominant GG + AG vs AA 0.69 (0.45-1.06) p = 0.087 0.53 (0.32-0.90) p = 0.018    1.01 (0.67-1.52) p = 0.960 1.06 (0.65-1.74) p = 0.814
  Recessive GG vs AG + AA 0.65 (0.38-1.09) p = 0.100 0.62 (0.33-1.18) p = 0.145    0.70 (0.41-1.20) p = 0.194 0.67 (0.35-1.28) p = 0.228
  1. Abbreviations: CI confidence interval, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, OR odds ratio, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism, TB tuberculosis.
  2. *Partly adjusted for age and gender.
  3. &Fully adjusted for age, gender, education level, income, body mass index, number of BCG vaccination scars and smoking.