Table 2 Genotype distribution of the selected SNPs in the study participants (Part 1/2)
Selected SNP | Genotype distribution* | p for difference | |||
|---|---|---|---|---|---|
SNP (ID) | Genotype | PTB patients, n (%) | LTBI controls n (%) | Healthy controls without MTB infection n (%) | |
IL1RN | TT | 170 (85.0) | 169 (85.8) | 173 (88.3) | 0.607§ |
9589 A/T | TA | 29 (14.5) | 28 (14.2) | 23 (11.7) | 0.432& |
(rs454078) | AA | 1 (0.5) | 0 | 0 | |
IL1B | CC | 54 (27.0) | 63 (32.0) | 59 (30.1) | 0.270§ |
-511 C/T | CT | 96 (48.0) | 97 (49.2) | 99 (50.5) | 0.393& |
(rs16944) | TT | 50 (25.0) | 37 (18.8) | 38 (19.4) | |
IL2 | TT | 89 (44.5) | 90 (45.7) | 87 (44.4) | 0.972§ |
-330 T/G | TG | 88 (44.0) | 85 (43.2) | 88 (44.9) | 0.964& |
(rs2069762) | GG | 23 (11.5) | 22 (11.2) | 21 (10.7) | |
IL4 | TT | 120 (60.0) | 106 (53.8) | 105 (53.6) | 0.456§ |
-589 C/T | TC | 70 (35.0) | 79 (40.1) | 77 (39.3) | 0.375& |
(rs2243250) | CC | 10 (5.0) | 12 (6.1) | 14 (7.1) | |
IL8 | AA | 74 (37.0) | 75 (38.1) | 68 (34.7) | 0.967§ |
-251 T/A | AT | 97 (48.5) | 93 (47.2) | 99 (50.5) | 0.890& |
(rs4073) | TT | 29 (14.5) | 29 (14.7) | 29 (14.8) | |
IL8RB | TT | 83 (41.5) | 83 (42.1) | 78 (39.8) | 0.985§ |
1208 C/T | TC | 85 (42.5) | 82 (41.6) | 88 (44.9) | 0.891& |
(rs1126579) | CC | 32 (16.0) | 32 (16.2) | 30 (15.3) | |
IL10 | TT | 99 (49.5) | 83 (42.1) | 81 (41.3) | 0.282§ |
-819 T/C | TC | 80 (40.0) | 94 (47.7) | 87 (44.4) | 0.217& |
(rs1800871) | CC | 21 (10.5) | 20 (10.2) | 28 (14.3) | |
IL10 | TT | 176 (88.0) | 162 (82.2) | 160 (81.6) | 0.133§ |
-1082 A/G | TC | 23 (11.5) | 35 (17.8) | 35 (17.9) | 0.201& |
(rs1800896) | CC | 1 (0.5) | 0 | 1 (0.5) | |
IL18 | CC | 157 (78.5) | 147 (74.6) | 152 (77.6) | 0.648§ |
-137 G/C | CG | 40 (20.0) | 46 (23.4) | 42 (21.4) | 0.865& |
(rs187238) | GG | 3 (1.5) | 4 (2.0) | 2 (1.0) | |
IL18 | CC | 58 (29.0) | 50 (25.4) | 49 (25.0) | 0.708§ |
-607 A/C | CA | 99 (49.5) | 101 (51.3) | 101 (51.5) | 0.658& |
(rs1946518) | AA | 43 (21.5) | 46 (23.4) | 46 (23.5) | |
TLR1 | GG | 90 (45.2) | 90 (35.4) | 74 (37.8) | 0.325§ |
-7202 A/G | GA | 84 (42.2) | 91 (32.7) | 103 (52.6) | 0.117& |
(rs5743551) | AA | 25 (12.6) | 16 (8.1) | 19 (9.7) | |
TLR2 | TT | 97 (48.5) | 102 (51.8) | 97 (49.5) | 0.657§ |
597 C/T | TC | 83 (41.5) | 73 (37.1) | 81 (41.3) | 0.956& |
(rs3804099) | CC | 20 (10.0) | 22 (11.2) | 18 (9.2) | |
TLR5 | CC | 189 (94.5) | 189 (95.9) | 188 (96.4) | 0.502§ |
1174 C/T | CT | 11 (5.5) | 8 (4.1) | 7 (3.6) | 0.377& |
(rs5744168) | TT | 0 | 0 | 0 | |
TLR9 | AA | 70 (35.0) | 67 (34.0) | 68 (34.7) | 0.051§ |
1174 A/G | AG | 89 (44.5) | 106 (53.8) | 95 (48.5) | 0.592& |
(rs352139) | GG | 41 (20.5) | 24 (12.2) | 33 (16.8) | |
TLR9 | GG | 72 (36.0) | 70 (35.5) | 71 (36.2) | 0.052§ |
1635 A/G | GA | 88 (44.0) | 104 (52.8) | 93 (47.5) | 0.608& |
(rs352140) | AA | 40 (20.0) | 23 (11.7) | 32 (16.3) | |