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Table 2 Genotype distribution of the selected SNPs in the study participants (Part 1/2)

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

Selected SNP Genotype distribution* p for difference
SNP (ID) Genotype PTB patients, n (%) LTBI controls n (%) Healthy controls without MTB infection n (%)
IL1RN TT 170 (85.0) 169 (85.8) 173 (88.3) 0.607§
9589 A/T TA 29 (14.5) 28 (14.2) 23 (11.7) 0.432&
(rs454078) AA 1 (0.5) 0 0  
IL1B CC 54 (27.0) 63 (32.0) 59 (30.1) 0.270§
-511 C/T CT 96 (48.0) 97 (49.2) 99 (50.5) 0.393&
(rs16944) TT 50 (25.0) 37 (18.8) 38 (19.4)  
IL2 TT 89 (44.5) 90 (45.7) 87 (44.4) 0.972§
-330 T/G TG 88 (44.0) 85 (43.2) 88 (44.9) 0.964&
(rs2069762) GG 23 (11.5) 22 (11.2) 21 (10.7)  
IL4 TT 120 (60.0) 106 (53.8) 105 (53.6) 0.456§
-589 C/T TC 70 (35.0) 79 (40.1) 77 (39.3) 0.375&
(rs2243250) CC 10 (5.0) 12 (6.1) 14 (7.1)  
IL8 AA 74 (37.0) 75 (38.1) 68 (34.7) 0.967§
-251 T/A AT 97 (48.5) 93 (47.2) 99 (50.5) 0.890&
(rs4073) TT 29 (14.5) 29 (14.7) 29 (14.8)  
IL8RB TT 83 (41.5) 83 (42.1) 78 (39.8) 0.985§
1208 C/T TC 85 (42.5) 82 (41.6) 88 (44.9) 0.891&
(rs1126579) CC 32 (16.0) 32 (16.2) 30 (15.3)  
IL10 TT 99 (49.5) 83 (42.1) 81 (41.3) 0.282§
-819 T/C TC 80 (40.0) 94 (47.7) 87 (44.4) 0.217&
(rs1800871) CC 21 (10.5) 20 (10.2) 28 (14.3)  
IL10 TT 176 (88.0) 162 (82.2) 160 (81.6) 0.133§
-1082 A/G TC 23 (11.5) 35 (17.8) 35 (17.9) 0.201&
(rs1800896) CC 1 (0.5) 0 1 (0.5)  
IL18 CC 157 (78.5) 147 (74.6) 152 (77.6) 0.648§
-137 G/C CG 40 (20.0) 46 (23.4) 42 (21.4) 0.865&
(rs187238) GG 3 (1.5) 4 (2.0) 2 (1.0)  
IL18 CC 58 (29.0) 50 (25.4) 49 (25.0) 0.708§
-607 A/C CA 99 (49.5) 101 (51.3) 101 (51.5) 0.658&
(rs1946518) AA 43 (21.5) 46 (23.4) 46 (23.5)  
TLR1 GG 90 (45.2) 90 (35.4) 74 (37.8) 0.325§
-7202 A/G GA 84 (42.2) 91 (32.7) 103 (52.6) 0.117&
(rs5743551) AA 25 (12.6) 16 (8.1) 19 (9.7)  
TLR2 TT 97 (48.5) 102 (51.8) 97 (49.5) 0.657§
597 C/T TC 83 (41.5) 73 (37.1) 81 (41.3) 0.956&
(rs3804099) CC 20 (10.0) 22 (11.2) 18 (9.2)  
TLR5 CC 189 (94.5) 189 (95.9) 188 (96.4) 0.502§
1174 C/T CT 11 (5.5) 8 (4.1) 7 (3.6) 0.377&
(rs5744168) TT 0 0 0  
TLR9 AA 70 (35.0) 67 (34.0) 68 (34.7) 0.051§
1174 A/G AG 89 (44.5) 106 (53.8) 95 (48.5) 0.592&
(rs352139) GG 41 (20.5) 24 (12.2) 33 (16.8)  
TLR9 GG 72 (36.0) 70 (35.5) 71 (36.2) 0.052§
1635 A/G GA 88 (44.0) 104 (52.8) 93 (47.5) 0.608&
(rs352140) AA 40 (20.0) 23 (11.7) 32 (16.3)  
  1. Abbreviations: IL interleukin, IL1RN inteleukin 1 receptor antagonist; IL8RB interleukin 8 receptor beta; LTBI latent M. tuberculosis infection; MTB Mycobacterium tuberculosis, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism, TB tuberculosis, TLR Toll-like receptor.
  2. *Sum may not always add up to total because of missing data.
  3. §p for difference between PTB patients and LTBI controls.
  4. &p for difference between PTB patients and Healthy controls without MTB infection.