Cardiopulmonary involvement in Puumala hantavirus infection

BMC Infectious Diseases

Table 3 Lung function and chest high-resolution computed tomography results in acute phase and at follow-up

	Acute phase	Follow-up	P-value^a
Lung function results
Number of patients	25	24	-
Days post onset of disease	7 (5–9)	98 (88–115)	-
VC	103 (93–113)	112 (103–120)	<0.001
TLC	105 (92–115)	109 (95–112)	<0.05
FEV₁	94 (77–104)	102 (93–117)	<0.001
FEV₁/VC	94 (88–99)	95 (86–101)	ns
DLCO	67 (54–76)	83 (70–94)	<0.001
Chest HRCT results
Number of patients	24	14^b	-
Days post onset of disease	6 (5–7)	100 (94–110)	-
Pleural effusion	9 (38%)	0	-
Pulmonary oedema	5 (21%)	1 (4%)	-
Enlarged thoracic lymph nodes	4 (17%)	0	-
Pericardial effusion	2 (8%)	0	-
Pneumonic infiltrate	1 (4%)	0	-

^aDetermined by Wilcoxon signed-ranks test, ^bRadiological follow-up (X-ray or HRCT, when indicated) were performed in 14 patients with pathological findings. DLCO, diffusing capacity of the lung for carbon monoxide; FEV₁, forced expiratory volume in 1 second; HRCT, high-resolution computed tomography; TLC, total lung capacity; VC, vital capacity.
Results are expressed as median (25^th-75^th percentile) as percentage of predicted value for lung function and number of patients (%) with the respective finding for chest HRCT.

ISSN: 1471-2334