Figure 2
Liver sections from cynomolgus (A and B) and Brazilian HEV infected pig (C). A. Focal area of hepatocyte necrosis with polymorphic inflammation (histiocytes, lymphocytes, and neutrophils). Stained with hematoxylin and eosin; B. Detection of HEV antigen (marked in green) in the cytoplasm of hepatocytes and Kupffer cells at 67 dpi (cynomolgus G3); and C. Detection of HEV antigen (marked in red) in the cytoplasm of hepatocytes from a naturally infected pig obtained from a commercial pig farm in Brazil (inoculum).